How bacteria in tumors drive treatment resistance in cancer

Study reveals how bacteria in tumors drive treatment resistance in cancer
Graphical abstract. Credit: Cancer Cell (2025). DOI: 10.1016/j.ccell.2025.09.010

Researchers from The University of Texas MD Anderson Cancer Center have discovered a previously unknown mechanism that explains how bacteria can drive treatment resistance in patients with oral and colorectal cancer. The study was published today in Cancer Cell.

Tumor-infiltrating bacteria have been known to impact cancer progression and treatment, but very little is understood about how they do this. The new study shows how certain bacteria—particularly Fusobacterium nucleatum (Fn)—can induce a reversible state, known as quiescence, in cancer epithelial cells. This allows tumors to evade the immune system and resist chemotherapy.

“These bacteria-tumor interactions have been hiding in plain sig...

Read More

A hitchhiker’s guide to the galaxy of space immunology

A hitchhiker's guide to the galaxy of space immunology
In space, weakened immune function elevates disease risk. Continuous monitoring and targeted interventions are being proposed to protect astronaut immune health, while preventive measures aim to minimize long-term immune compromise. Credit: Huixan Du, Buck Institute for Research on Aging

With the advent of commercial spaceflight, an increasing number of people may be heading into space in the coming years. Some will even get a chance to fly to the moon or live on Mars.

One of the major health risks associated with spaceflight involves the immune system, which normally fights off viruses and cancer. It’s already established that spaceflight weakens immunity; current and past astronauts report clinical issues such as respiratory illnesses and skin rashes...

Read More

This experimental “super vaccine” stopped cancer cold in the lab

“Super Vaccine” Stopped Cancer Cold in the Lab
UMass Amherst scientists created a nanoparticle “super adjuvant” vaccine that prevented melanoma, pancreatic, and breast cancers in mice. The innovation primes the immune system for lasting, body-wide protection against cancer spread. Credit: Shutterstock

Researchers at the University of Massachusetts Amherst have shown that their nanoparticle-based vaccine can successfully prevent several aggressive cancers in mice, including melanoma, pancreatic cancer, and triple-negative breast cancer. Depending on the cancer type, up to 88% of vaccinated mice stayed tumor-free (depending on the cancer), and the vaccine also reduced — and in some cases completely prevented — the spread of cancer throughout the body.

“By engineering these nanoparticles to activate the immune system via multi-...

Read More

World’s first full-cell dual-cation battery developed in Ireland

World's first full-cell dual-cation battery developed at University of Limerick, Ireland
Postdoctoral fellow, Dr. Syed Abdul Ahad and Associate Professor Hugh Geaney of UL’s Department of Chemical Sciences and Bernal Institute. Credit: Alan Place/UL

Researchers at University of Limerick (UL) have developed a battery that could reshape the future of electric vehicles and portable electronics. Their breakthrough in energy storage technology has seen the development of the world’s first full-cell dual-cation battery.

This innovative system combines lithium and sodium ions to significantly enhance both battery capacity and stability, marking a new frontier in sustainable energy research.

The work, published in Nano Energy, was led by Hugh Geaney, Associate Professor of Chemistry at UL’s Department of Chemical Sciences and Principal Investigator at UL’s Bernal Institute, ...

Read More