Using computational tools and virtual screening, researchers at the Center for Redox Processes in Biomedicine (Redoxoma) have identified new inhibitors of the enzyme human 15-lipoxygenase-2 (h15-LOX-2). This protein plays an important role in inflammatory and metabolic processes and contributes to cellular homeostasis.

The discovery, described in the Journal of Medicinal Chemistry, could open up new avenues for investigating the biological and pathological functions of the enzyme and provide promising candidates for the development of new drugs.

“Although h15-LOX-2 is a potential biological target, it’s scarcely been explored for this purpose...

So-called “memristors” consume extremely little power and behave similarly to brain cells. Researchers from Jülich, led by Ilia Valov, have now introduced novel memristive components that offer significant advantages over previous versions: they are more robust, function across a wider voltage range, and can operate in both analog and digital modes. These properties could help address the problem of “catastrophic forgetting,” where artificial neural networks abruptly forget previously learned information.

The problem of catastrophic forgetting occurs when deep neural networks are trained for a new task...

Two different teams of astronomers have detected oxygen in the most distant known galaxy, JADES-GS-z14-0. The discovery, reported in two separate studies, was made possible thanks to the Atacama Large Millimeter/submillimeter Array (ALMA), in which the European Southern Observatory (ESO) is a partner. This record-breaking detection is making astronomers rethink how quickly galaxies formed in the early universe.

Discovered last year, JADES-GS-z14-0 is the most distant confirmed galaxy ever found: it is so far away, its light took 13.4 billion years to reach us, meaning we see it as it was when the universe was less than 300 million years old, about 2% of its present age.

The new oxygen detection with ALMA, a telescope array in Chile’s Atacama Desert, suggests the galaxy is much m...

A research team has developed the world’s first quantum microsatellite and demonstrated real-time quantum key distribution (QKD) between the satellite and multiple compact, mobile ground stations.

The research, led by Pan Jianwei, Peng Chengzhi, and Liao Shengkai from USTC, jointly with the Jinan Institute of Quantum Technology, Shanghai Institute of Technical Physics, the Innovation Academy for Microsatellites of the Chinese Academy of Sciences, and Stellenbosch University of South Africa, is published in Nature.

Quantum secure communication is fundamental to national information security and socioeconomic development...