Gene that drives blood cancer drug resistance uncovered with new CRISPR activation tool

Gene
Credit: Unsplash/CC0 Public Domain

Researchers have uncovered a previously unknown gene that causes resistance to a leading blood cancer drug, as well as several genes that accelerate lymphoma growth, using a powerful new CRISPR activation library.

Traditional CRISPR is a genetic engineering tool that allows scientists to easily delete specific genes in an organism’s DNA and assess their role and importance. It has become a cornerstone technology in cancer research.

A newer frontier is CRISPR activation, a technique that enables the activation of specific genes. It offers valuable insights into the roles of certain genes in cancer and other genetic disorders.

A team of researchers from the Olivia Newton-John Cancer Research Institute (ONJCRI), WEHI and Genentech, a member of t...

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Venus ate its moon: How Earth’s ‘twin’ could have swallowed a rocky satellite

Illustration of corona erupting in the southern hemisphere of Venus
Illustration depicts active volcanism in Venus’ southern hemisphere.
(NASA/JPL-Caltech/Peter Rubin)

Scientists have long speculated why Venus, with a size, mass and structure similar to Earth’s, doesn’t have a moon. New UC Riverside research shows that our hungry twin likely swallowed it.

In the past, scientists theorized that Venus possibly had a moon that was hit by something massive, obliterating it. Other theories centered on the idea that Venus never underwent a collision that formed a moon in the first place.

The new research, published in The Astrophysical Journal, shows that neither theory fits.

“My study shows Venus didn’t require a catastrophe to arrive at what we can see today,” said UCR astrophysicist and lead author Stephen Kane...

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Blood test trends may help identify patients at increased risk of cancer

Blood test trends alongside unexplained weight loss can improve triage for cancer testing, according to a study by Brian Nicholson and colleagues from the University of Oxford, UK, published Sept. 17 in the journal PLOS Medicine.

Abnormal blood test results, such as low hemoglobin or increased platelet counts, can provide clues about a patient’s risk of developing cancer. However, monitoring trends over repeat tests could provide further clues in some instances by identifying cancer-related changes in blood test results that do not appear abnormal. Assessing patterns in blood test abnormalities and trends alongside unexplained weight loss could enhance cancer risk assessment and support earlier diagnosis.

In this study, researchers examined trends in blood test results among pat...

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A glimpse of the solar system’s origins: Striking details on the molecules inside a meteorite

Meteorite molecules with their corresponding chemical diagrams
Brookhaven Lab scientist Percy Zahl of the Center for Functional Nanomaterials, a DOE Office of Science user facility, used high-resolution noncontact atomic force microscopy to image the structures of individual molecules from one of the meteorites. This provided a more detailed look at these extraterrestrial organic compounds. For more information about Brookhaven’s role in this research, contact Peter Genzer (genzer@bnl.gov, 631-344-3174).

Researchers at the National High Magnetic Field Laboratory and Brookhaven National Laboratory have teamed up to get a fresh look at the complex makeup of meteorites and glimpse into our solar system’s past.

Powerful spectrometry found only at the MagLab identified the vast array of organic compounds inside two meteorites, and Brookhaven scien...

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