Multiple sclerosis (MS) is a chronic autoimmune disorder that attacks the central nervous system. For years, Epstein-Barr virus (EBV) has been strongly linked to MS, as nearly every person diagnosed with the condition shows evidence of past EBV infection. For example, a 2022 study analyzed millions of U.S. military recruits and found that getting infected with EBV increased a person’s risk of developing MS 32-fold.

But exactly how EBV is linked to the abnormal immune response seen in MS has remained unclear until now.

In a study published in Science Translational Medicine, scientists descr...

Large language models (LLMs), the computational algorithms underpinning ChatGPT, Gemini and other artificial intelligence (AI)-powered conversational platforms, are now widely used worldwide. These models can rapidly answer questions, source information online, assist users with specific tasks and produce text tailored for specific purposes.

Over the past few years, computer scientists have introduced a wide range of LLMs, some of which can also complete tasks autonomously and take actions on a user’s behalf, for instance, answering messages, scheduling online appointments or updating programming code...

Scientists have developed a new way to predict the strength of the sun’s next activity cycle up to seven years before it reaches its peak.

The new method uses the number of sunspots at a newly identified “switchoff” point in the solar cycle, when the sun’s most extreme space weather suddenly comes to an end. Using this approach, researchers have made an early prediction for the strength of Solar Cycle 26.

A very early prediction shows a moderate Cycle 26 with a sunspot number of around 100–120, s...

Scientists have made many advances using traditional CRISPR technology, especially in medicine, but they are now seeking ways to create genuinely new gene-editing enzymes with properties that have not already evolved naturally. A new study, published in Science, describes a new AI-designed synthetic TnpB enzyme, called SynTnpBs, that has outperformed the natural reference enzyme.

Creating new gene editors
CRISPR tools use a programmable guide RNA to direct an enzyme to a specific target in the genome to edit (cut, insert or correct) DNA. The TnpB enzyme is a compact ancestor of certain CRISPR enzymes, called CRISPR-Cas12 enzymes...