Treatment with norrin helps maintain healthy blood vessels and preserve vision in diabetic rats

Millions of people in the U.S. are affected by diabetic retinopathy, a complication of diabetes that affects the eyes. The condition is caused by damage to the blood vessels in the retina, the light-sensitive tissue at the back of the eye. At first, diabetic retinopathy might not cause any symptoms, or the problems might be mild. However, if the underlying diabetes remains poorly managed, it can lead to blindness.

In a new study, University of Michigan researchers showed that treatment with the molecule norrin can prevent vision loss in diabetic rats. The study is published in the journal Diabetes.

Diabetic retinopathy treatment
Current therapies for diabetic retinopathy target vascular endothelial growth factor, or VEGF, a protein that causes new blood vessels to form.

VEGF a...

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Engineering researcher seeks to prevent AI agents from going rogue

AI agents
Credit: Unsplash/CC0 Public Domain

As artificial intelligence systems become increasingly capable of working on their own, keeping them focused on their designated tasks is a growing challenge.

University of Florida computer science professor Sumit Jha, Ph.D., is working to keep agents from “going rogue.” Jha and his team have developed a system that can detect when an AI model begins to from its assigned task and steer it back without retraining the model or adding significant computing demands.

The research comes as news reports have chronicled AI agents gaining more autonomy and occasionally behaving in ways their developers did not intend...

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Scientists smash oxygen nuclei to recreate matter from the Big Bang

This image shows back-to-back jets produced in the quark-gluon plasma formed when two oxygen nuclei collide at the Relativistic Heavy Ion Collider (RHIC). The jet near the edge of the plasma, upper right, escapes easily while the jet moving a longer distance through the plasma loses energy, or gets “quenched,” as it interacts with the soup of quarks and gluons. (Valerie A. Lentz/Brookhaven National Laboratory)

Scientists have recreated a primordial state of matter from the dawn of the universe by colliding oxygen nuclei at nearly the speed of light. The surprising results show that this exotic substance can form in smaller, lower-energy collisions than previously demonstrated, challenging the known boundaries of early-universe physics.

New findings from the STAR experiment at the Re...

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Could a few bad dietary choices worsen your next immune response?

Fluorescent microscopy image of mouse ear skin showing few memory T-cells in red after inflammation subsided.
Fluorescent microscopy image of mouse ear skin showing few memory T-cells in red.

Scientists have long known that diet shapes the immune system. Now, a UC San Francisco team has found that even a brief dietary change can substantially change how the body responds to skin irritation, at least in mice.

When scientists fed mice a high-fat diet for just a few days, the mice had a much worse reaction to an irritating cream. And the skin stayed on alert even after the mice returned to a low-fat diet and the inflammation cleared, responding more strongly the next time it was exposed to the cream.

The findings suggest that short-term diet may have just as much an effect as body weight when it comes to inflammation.

“Long-term dietary habits absolutely matter for health, but our study ...

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