Machine learning detects bacterial invasion and DNA damage in human cells

Cell by cell: New machine-learning-based method reveals what can make bacteria dangerous
MALVINA connects bacterial behaviour, host-cell responses and drug effects in a single-cell analysis framework. By measuring bacterial invasion, intracellular accumulation and host-cell damage together, the method can support pathogen diagnostics, probiotic discovery, drug profiling and toxicity testing under more infection-relevant conditions. Credit: HUN-REN Biological Research Centre Szeged

When scientists assess how dangerous a bacterium is, the first question often seems simple: Can it be stopped or killed? In microbiology and antibiotic research, one of the classic readouts has been whether a bacterium can grow in the presence of a given treatment. The bacterium either grows or it does not. The drug either stops it or it does not.

But infection is not just a survival contest...

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Earth and Mars: Built from different cosmic recipes

Image of Mars
“You might have expected that two planets formed side by side in the same solar system would share a more similar formation history,” says Professor Anders Johansen, who co-led a new study about the origin of Earth and Mars. Photo: Canva

Four and a half billion years ago, Earth and Mars were born in the rotating cloud of gas and dust that would eventually become our solar system. Yet exactly how the planets formed remains one of the most disputed questions in planetary science.

Now, researchers at the University of Copenhagen are adding new evidence to the debate. Using a novel approach, they have reconstructed the earliest stages of the planets’ formation by analyzing their chemical composition.

And the results surprised them.

“The most surprising result was that Earth and Ma...

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A molecular switch syncs fat burning to the body clock, our diet and the temperature around us

outside workout
Credit: Unsplash/CC0 Public Domain

Brown fat burns fuel to make heat, and this activity is controlled by the body clock: It drops during sleep and rises before waking. But a cold morning or a skipped meal makes demands the clock never planned for. How the body keeps to a fixed energy timetable while still improvising has long been a puzzle.

Researchers at the University of Copenhagen’s NNF Center for Basic Metabolic Research (CBMR) now show that SLC25A34, a little-studied protein in the mitochondria of fat cells, acts as a switch that connects the body clock, temperature and diet to how fat cells store and spend energy. The study was published in Science.

“We usually think of the body clock, the response to temperature and the response to food as separate systems...

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Ions help electrons hop through porous material with potential for brain-inspired computing

New research advances neuron-inspired computing materials
Visualization of the zinc-based metal-organic framework, highlighting how a nearby potassium ion can influence electron movement through the material. Credit: Courtesy of Alejandro Aviles Sanchez

Next-generation computing technologies could be one step closer to emulating how neurons respond and communicate with each other, thanks to research examining how electrons and ions move through materials.

Among them, metal-organic frameworks (MOFs) are a class of materials with potential for advanced electronics.

In a recently published paper in the Journal of the American Chemical Society, Texas A&M University chemical engineering professor Dr. Perla Balbuena and postdoctoral researcher Dr...

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