The gut can drive age-associated memory loss, research reveals

The gut can drive age-associated memory loss
An intestinal immune cell detects medium-chain fatty acids produced by aging gut bacteria through the GPR84 receptor, releasing inflammatory molecules that block signaling along the vagus nerve to the hippocampus. Disruption of this gut-brain pathway drives age-associated cognitive decline. Credit: Thaiss Lab

We become forgetful as we age. This is often seen as a universal truth, but in fact it is far from universal: some people remain incredibly sharp at 100 years old, while others experience memory loss starting in middle age.

While it seems logical that age-related cognitive decline would be blamed on brain aging and degeneration (which, like anything in the brain, is notoriously hard to treat), there’s some evidence that processes elsewhere in the body influence the brain’s abil...

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No battery needed: Single organic device can act as both indoor solar cell and a photodetector

Dongguk University researchers develop breakthrough material for powering next-generation smart devices
The proposed material facilitates bifunctionally driven organic photonic conversion devices for next-generation applications. Credit: Associate Professor Jea Woong Jo from Dongguk University and Associate Professor Jae Won Shim from Korea University

Next-generation optoelectronic systems (devices that convert light to electrical energy) leverage organic semiconductor-based indoor energy-autonomous architectures for cutting-edge applications. Notably, organic semiconductors possess mechanical flexibility, solution processability, and bandgap-tunable optoelectronic properties, making them highly lucrative for indoor power generation via organic photovoltaics (OPVs), as well as for spectrally selective photodetection through organic photodetectors (OPDs)...

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Scientists crack a 20-year nuclear mystery behind the creation of gold

Peter Dyszel

Gold cannot form until certain unstable atomic nuclei break apart. Exactly how those nuclear transformations unfold has long been difficult to determine. Now, nuclear physicists at the University of Tennessee (UT) report three discoveries in a single study that clarify important parts of this process. Their findings could help researchers build improved models of the stellar events that create heavy elements and better predict the behavior of exotic atomic nuclei.

Heavy elements such as gold and platinum are forged under extraordinary conditions, including when stars collapse, explode, or collide. These events trigger the rapid neutron capture process (or r-process for short). During this process, an atomic nucleus absorbs neutrons in rapid succession...

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Scientists find a new therapeutic target present on up to half of all tumors

laboratory
Credit: Unsplash/CC0 Public Domain

For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden from the immune system. But now researchers at UC San Francisco have discovered that the SRC enzyme also appears like a flag on the surface of bladder, colorectal, breast, pancreatic and probably many other tumor cells.

As cancer cells furiously divide, they produce a lot of garbage. In healthy cells, the trash gets broken down. But in tumors, the recycling system gets overwhelmed, and the cells expel some of their trash. This pushes the SRC onto the surface of the cell, where it is visible to potential therapies, like antibodies.

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