A missing piece in the cell death and inflammation signaling pathway puzzle has been revealed

One of the final pieces in the cell death and inflammation signalling pathway puzzle has been revealed
Scheme of the inflammation signalling pathway. Credit: Henning Walczak/Universität zu Köln

An international research team has discovered a previously unknown mechanism that plays a key role in the signaling pathways involved in programmed cell death. The team identified the protein HERC4 as an essential component of both TNF-induced necroptosis and apoptosis pathways—two processes that play a crucial role in maintaining cellular balance and triggering inflammatory responses.

The study, “HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death,” was published in Nature Structural and Molecular Biology. The lead researchers were Dr...

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Quantum computer boldly goes where no quantum computer has gone before: Space

Quantum computer boldly goes where no quantum computer has gone before: Space
Photonic computing platform in space. Credit: arXiv (2026). DOI: 10.48550/arxiv.2609.25248

There’s big news from the quantum world. A quantum computer has been used in space for the first time. The device was aboard a spacecraft in low Earth orbit and demonstrated technology that could eventually help solve a problem that has been bugging satellites for years.

The issue is that when orbiting satellites send their raw data back down to Earth, bottlenecks and bandwidth limits slow everything down. One way to overcome this would be to process the raw data in situ before sending it.

So a team of physicists led by Philip Walther at the University of Vienna came up with a way that could eventually do just that...

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Black hole jets reach far beyond galaxies’ visible edges, potentially deciding their fate

ASU astronomers uncover black hole jets reaching far beyond their galaxies and deciding their fate
Artist’s illustration of a supermassive black hole at the center of a radio galaxy launching powerful jets (shown in pink) all the way into the galaxy’s CGM. The study finds that these jets do not light up the surrounding gas equally in all directions. Instead, the hydrogen gas glows (shown in red) most strongly along the path of the radio jets. This suggests that black holes can send energy far beyond the galaxy’s center and shape the larger gas reservoir that regulates star formation and fate of galaxies. We use optical data from the DESI survey and radio observations from the LOFAR Two meter Sky Survey (LoTss). Credit: Hailey Nelson/ Arizona State University.

Galaxies are enormous and hold hundreds of billions of stars. These stars form from cold, dense gas...

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Kidney disease, heart failure or death risk climbs to 55% 10 years after type 2 diabetes diagnosis

type 2 diabetes
Credit: Unsplash/CC0 Public Domain

The risk of developing chronic kidney disease (CKD) or heart failure (HF), or dying, following a type 2 diabetes (T2D) diagnosis increases substantially over time, according to new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Milan, Italy, Sept. 28–Oct. 2.

The study, which analyzed data from more than 1.6 million patients across the U.S., found that the combined risk of developing CKD or HF, or dying, was 33% on average within the first five years of a T2D diagnosis, rising to 55% over 10 years.

The researchers say their findings underscore the importance of early, proactive and more holistic approaches to managing type 2 diabetes to help reduce the risk of serious complications...

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