New combination therapy shows promise in metastatic pancreatic cancer

Results from an early-stage clinical trial, published in Nature Communications, showed encouraging outcomes among patients with newly diagnosed cancer whose tumors had spread to distant organs. Most strikingly, one patient experienced a pathologic complete response—meaning no viable cancer cells could be found—and remains cancerfree for more than two years without further treatment. These findings offer an important signal that a new approach may be able to overcome one of the disease’s greatest challenges: its resistance to immunotherapy.

“We desperately need new tools in our arsenal,” said Gulam Manji, MD, PhD, a medical oncologist specializing in pancreatic cancer and lead investigator of the trial...

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New transistor brings high voltage to microchip scale

New transistor brings high voltage to microchip scale
The POWERlab’s intrinsic polarization superjunction (iPSJ). Credit: 2026 Alain Herzog/EPFL CC BY SA 4.0

Inside every electronic device, the flow of electricity is controlled by a switch called a transistor. For decades, these switches were made from silicon. More recently, engineers have turned to a material called gallium nitride (GaN), which enables small, efficient devices like smartphone chargers.

However, at very high voltages, electric fields inside these transistors can concentrate at specific points, causing them to fail prematurely. As a result, today’s GaN devices still struggle to perform at the highest voltage levels achieved by silicon.

To overcome this limitation, researchers in the Power and Wide-band-gap Electronics Research Lab (POWERlab) in EPFL’s School of Engi...

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Discovery reveals rapid pathways to complex aromatic molecules in space

Discovery reveals rapid pathways to complex aromatic molecules in space
Molecular beams machine with integrated chemical microreactor. Credit: University of Hawaii at Manoa

A team of researchers led by the University of Hawaiʻi at Mānoa Department of Chemistry has uncovered a faster way large carbon-based molecules may form in space, helping solve a long-standing mystery about how some of the building blocks of the universe grow.

The study, published in Nature Communications in August 2026 and first-authored by chemistry graduate student Shane Goettl, identifies a new chemical process that could explain the rapid formation of polycyclic aromatic hydrocarbons (PAHs)—large molecules made of carbon and hydrogen that are found throughout the universe, from dying stars to clouds of gas between stars.

Scientists have known these molecules are abundant ...

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Chronic pain is reflected in the folds and grooves of the cerebral cortex

Chronic pain is reflected in the folds and grooves of the cerebral cortex
Surface-based morphometry workflow for ROI-wise cortical surface feature extraction. Surface atlases were mapped to individual surfaces using the spherical registration parameters obtained during surface processing. Surface-based measures (e.g., cortical thickness, sulcal depth) were then extracted for each ROI in native space. Credit: NeuroImage: Clinical (2026). DOI: 10.1016/j.nicl.2026.104023 Created in BioRender. https://BioRender.com/4zyhoc8.

Persistent pain often has no clear cause. However, studies show measurable differences in the structure and activity of the brains of those affected. This might explain why they experience chronic pain...

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