Injectable ‘satellite livers’ could offer an alternative to liver transplantation

Researchers used a microfluidic device to generate hydrogel microspheres of uniform shape and size. These spheres are then mixed with hepatocytes and injected into the body, where they form stable mini livers.
Credits:Credit: Courtesy of the Bhatia Lab

More than 10,000 Americans who suffer from chronic liverdisease are on a waitlist for a liver transplant, but there are not enough donated organs for all of those patients. Additionally, many people with liver failure aren’t eligible for a transplant if they are not healthy enough to tolerate the surgery.

To help those patients, MIT engineers have developed “mini livers” that could be injected into the body and take over the functions of the failing liver.

In a new study in mice, the researchers showed that these injected liver cell...

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Next-generation memory material has the surprising property of shrinking when heated

A new material for next-generation memory—with the surprising property of shrinking when heated
Credit: Masaki Azuma

Most materials we use in everyday life expand slightly when heated and return to their original size when cooled. In addition to such thermal properties, materials can also have electrical properties or magnetic properties, and traditionally we have used these characteristics separately. However, some materials allow multiple properties to coexist within a single substance.

Research on such materials is expected to contribute to the development of next-generation memory devices that can store and retain information while consuming far less energy.

How multiferroics could transform memory
A representative example is a class of materials known as multiferroics, which combine the properties of a capacitor (the ability to store electric charge) and a magnet...

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Life forms can planet hop on asteroid debris—and survive

Microbes before and after extreme impact
Image credit: Lisa Orye / Johns Hopkins University

Tiny life forms tucked into debris from an asteroid hit could catapult to other planets—including Earth—and survive, a new Johns Hopkins University study finds. The work demonstrates that a certain hardy bacterium easily withstands extreme pressure comparable to an ejection from Mars after an asteroid hit, as well as the inhospitable conditions it would face during the ensuing interplanetary journey.

The study, published today in PNAS Nexus, suggests that microorganisms can survive remarkably more extreme conditions than expected, and raises questions about origins of life. The work also has significant implications for planetary protection and space missions.

“Life might actually survive being ejected from one planet and mo...

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Painless skin patch offers new way to monitor immune health

Painless skin patch offers new way to monitor immune health
Sasan Jalili holds the microneedle skin patch, which is about the size of a quarter. Credit: The Jackson Laboratory

Researchers at The Jackson Laboratory (JAX), in collaboration with the Massachusetts Institute of Technology (MIT), have developed the first bandage-like microneedle patch that can sample the body’s immune responses painlessly from the skin. The device detects inflammatory signals within minutes and collects specialized immune cells within hours without the need for blood draws or surgical biopsies.

Already, the patch is helping researchers and clinicians study immune responses in aging and skin autoimmunity, including vitiligo and psoriasis...

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