Scientists recruit red blood cells to deliver genetic cargo with instructions to kill cancer

red blood cells
Credit: CC0 Public Domain

Scientists have developed a way to turn the body’s own immune cells into cancer-fighting agents—without removing them from the body—by using red blood cells to deliver genetic instructions. Current CAR (chimeric antigen receptor) therapies typically involve collecting a patient’s T cells, genetically modifying them in the laboratory, and then reinfusing them in a process that can take weeks. The new strategy aims to bypass that step.

In a study published in Science Translational Medicine, researchers at Westlake Laboratory of Life Sciences and Biomedicine in Hangzhou, China, report that they used engineered erythrocytes, or red blood cells, to carry messenger RNA—mRNA—that reprograms myeloid cells into tumor-targeting cells inside the body.

“Engi...

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NASA Curiosity rover finds mysterious life linked molecules on Mars

The six-wheeled Curiosity rover is positioned in the right side of the frame on a rugged, rock-strewn, brownish-red Martian plain. The rover’s articulated robotic arm and camera mast are raised. Distant hills and a hazy, dusty orange-brown sky are in the background.
NASA’s Curiosity Mars rover took this selfie on Oct. 25, 2020, after drilling a rock sample from a spot nicknamed “Mary Anning.” After years of extensive analysis, the sample has revealed the greatest diversity of organic molecules ever found on Mars.
NASA/JPL-Caltech/MSSS

NASA’s Curiosity rover has identified a wide range of organic molecules on Mars, including compounds that scientists consider key ingredients for the origin of life on Earth.

The discovery comes from a chemical experiment carried out on another planet for the first time. Results show that the Martian surface is capable of preserving molecules that could act as potential signs of ancient life...

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Umbilical cord blood transplant with pooled stem cell product shows 96% survival and no GVHD in leukemia patients

A new way of using umbilical cord blood for treating blood diseases could make the treatment more accessible to patients who need a stem cell transplant. A Phase II clinical trial of patients undergoing a cord blood transplant plus a stem cell product derived from pooled cord blood units showed that 27 of 28 patients (96%) with leukemias and GVHD survived at least one year and none of the patients experienced severe acute or chronic graft-versus-host disease, which are common complications of stem cell transplantation.

The results have been published in the Journal of Clinical Oncology.

“This is the first time transplant patients received cells from what amounts to nine different human beings,” said the study’s principal investigator, Filippo Milano, MD, Ph.D...

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Low-cost 3D printers could gain medical-grade precision from ultrathin light-control film

Ultra-thin optical film sharpens 3D printing precision
Researchers designed and fabricated a double-sided structure collimation film (DSSCF) with better collimation characteristics thanks to additional trapezoidal microstructures that prevent the large-angle leakage light seen with single-sided structure collimation film (SSSCF). The DSSCF also improves the light intensity uniformity when combined with a diffuser module. Credit: Ding-Zheng Lin, National Taiwan University of Science and Technology

Researchers have developed an ultra-thin optical film that improves the quality of the light used in LCD resin-based 3D printers. The advance helps ensure that tiny details are reproduced with precision, which could make it possible to 3D-print medical-grade or industrial-grade products at a lower cost.

Resin-based 3D printing, or vat photopoly...

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