D-serine accelerates gastric tumor growth by suppressing killer T cells

D-serine Promotes Tumor Growth in Gastric Cancer
D-serine is a metabolic byproduct that aids immune evasion by gastric cancer tumors. It increases immunosuppressive macrophage activity and reduces the numbers and function of cytotoxic T cells. This aids tumor growth and provides resistance against immune checkpoint inhibitor therapy. Credit: Keio University Global Research Institute (KGRI)

One of the crucial steps in cancer proliferation is evading killer immune cells. Cancer cells use a variety of signaling molecules to evade the immune system. Immune checkpoint inhibitor (ICI) therapy interferes with some of these evasion tactics, improving the immune system’s ability to suppress tumors. However, the success of ICI therapy depends on the specific signals being secreted by the tumor.

Recent research has identified D-amino acids (...

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‘Chameleon’ chip adapts to changing data speeds, cutting prediction errors by up to 40-fold

Concept and operating principle of the programmable dynamic memtransistor (PDM) for processing time-series signals across multiple timescales. Real-world time-series data contain both rapidly and slowly changing information, requiring different temporal response characteristics for effective analysis. Conventional semiconductor devices have a fixed, single temporal response, which limits the range of timescales they can process. In contrast, the PDM employs a dual-functional gate structure that enables its temporal response characteristics to be programmed at multiple levels, from fast to slow, and retained in a non-volatile manner...
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Rare ultra-magnetic star may be key to solving 90-year old quantum cold case

A Swinburne astronomer may have just confirmed one of the quirkiest aspects of quantum mechanics: that seemingly empty space can alter the behaviour of light. Image supplied via NASA.

Astronomers may have just confirmed one of the quirkiest aspects of quantum mechanics: that seemingly empty space can alter the behavior of light. This phenomenon, called “vacuum birefringence,” was first predicted nearly 90 years ago by Werner Heisenberg, one of the founding fathers of quantum mechanics. He suggested that even a perfect vacuum should be teeming with “virtual particles” that rapidly pop in and out of existence.

The astronomers, including Dr Marcus Lower from Swinburne University of Technology, used the properties of a magnetar—a rare type of neutron star with the strongest magnetic fie...

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Engineered human neurons rebuild damaged spinal cord circuits

Engineered human neurons rebuild damaged spinal cord circuits
Lana Zholudeva, Ph.D., is a Gladstone Institutes investigator and first author of the new study. Credit: Gladstone Institutes

Spinal cord injuries affect an estimated 15 to 20 million people worldwide, often causing lasting impairments in movement, sensation and independence. Such injuries can be especially devastating when they occur at the level of the neck, where damaged spinal circuits disrupt signals that control the diaphragm, the main muscle used for breathing.

Despite advances in emergency care and rehabilitation, no approved therapies exist to rebuild the neurons and connections lost after a spinal cord injury. But new research from scientists at Gladstone Institutes offers hope for a regenerative treatment in the future.

The study, published in Science Translational Med...

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