For people with painful knee osteoarthritis (OA) who are overweight or have obesity, everyday activities such as walking, climbing stairs and standing up from a chair can be difficult. In two Northwestern University–led Phase III clinical trials involving more than 1,000 participants combined, those taking the highest dose of retatrutide, a new experimental weight-loss injectable drug, lost about one-quarter of their body weight on average.

A pooled analysis of the studies found that about two-thirds of participants receiving retatrutide experienced at least a 50% reduction in knee pain, compared with 38% of those receiving placebo.

In addition to weight loss and pain relief, participants experienced other significant benefits, including reduc...

A nuclear explosion could potentially protect Earth from an incoming asteroid by releasing powerful Xrays that heat its surface and push it onto a safer trajectory. However, new research suggests that the success of such a mission could depend heavily on which side of the asteroid receives the blast.

Unlike the smooth, round objects often used in computer simulations, r...

A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer’s disease. The approach also reduced the toxicity of protein aggregates that had already formed.

In experiments using a mouse model of Alzheimer’s disease, the treatment reduced protein accumulation in the brain and improved memory recognition, suggesting a possible route toward new therapeutics.

The research team led by Professor Mi Hee Lim from the Department of Chemistry identified a new approach to controlling the aggregation and toxicity of amyloid-beta. The findings were published in Advanced Science.

T...

According to projections, the volume of digital data created, captured, copied and consumed worldwide will reach 175 zettabytes (ZB) in 2026. This is equivalent to the storage capacity of billions of hard drives, such as those found in our laptops. With the rise of artificial intelligence, this global ‘datasphere’ continues to expand at an exponential rate.

Thanks to its remarkable storage capacity and longevity, synthetic DNA is emerging as a potentially revolutionary medium for storing information.

“In theory, one gram of DNA could store the equivalent of the digital collections of the world’s largest libraries f...