Category Health/Medical

Silent Strep A infections may explain immunity gained by adulthood

Exposure to Streptococcus pyogenes (Strep A) that causes mild or no symptoms can trigger the body’s immune response and naturally build protection, potentially solving a nearly 100-year-old mystery of immunity.

New Griffith University research, with the help of clinical scientists from the Murdoch Children’s Research Institute (MCRI), investigated how immunity developed over time as infection rates declined with age, suggesting progressive immune protection. The paper “Subclinical exposure to Streptococcus pyogenes drives the development of long-lived homologous immunity” has been published in Nature Communications.

Strep A is a common bacterium that can cause painful tonsillitis and impetigo in young children and teenagers...

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Testing finds 85% of everyday personal care products contain unlabeled chemicals with suspected health hazards

shampoo
Credit: https://kaboompics.com/ from Pexels

A new study of sunscreens, baby lotions, shampoos, soaps and other everyday products found that nearly all contained chemicals not disclosed on their labels. Most contained at least one unlabeled chemical with known or suspected health hazards, and one in four contained a chemical that contradicted claims on the package, including “phthalate-free” products that contained phthalates. The research is published in Environment & Health.

“We found undisclosed harmful chemicals in products claiming to be free of them,” said Jenna Hua, senior author of the study and founder of the Million Marker Research Institute...

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D-serine accelerates gastric tumor growth by suppressing killer T cells

D-serine Promotes Tumor Growth in Gastric Cancer
D-serine is a metabolic byproduct that aids immune evasion by gastric cancer tumors. It increases immunosuppressive macrophage activity and reduces the numbers and function of cytotoxic T cells. This aids tumor growth and provides resistance against immune checkpoint inhibitor therapy. Credit: Keio University Global Research Institute (KGRI)

One of the crucial steps in cancer proliferation is evading killer immune cells. Cancer cells use a variety of signaling molecules to evade the immune system. Immune checkpoint inhibitor (ICI) therapy interferes with some of these evasion tactics, improving the immune system’s ability to suppress tumors. However, the success of ICI therapy depends on the specific signals being secreted by the tumor.

Recent research has identified D-amino acids (...

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Engineered human neurons rebuild damaged spinal cord circuits

Engineered human neurons rebuild damaged spinal cord circuits
Lana Zholudeva, Ph.D., is a Gladstone Institutes investigator and first author of the new study. Credit: Gladstone Institutes

Spinal cord injuries affect an estimated 15 to 20 million people worldwide, often causing lasting impairments in movement, sensation and independence. Such injuries can be especially devastating when they occur at the level of the neck, where damaged spinal circuits disrupt signals that control the diaphragm, the main muscle used for breathing.

Despite advances in emergency care and rehabilitation, no approved therapies exist to rebuild the neurons and connections lost after a spinal cord injury. But new research from scientists at Gladstone Institutes offers hope for a regenerative treatment in the future.

The study, published in Science Translational Med...

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