Category Biology/Biotechnology

Skeletal muscle signals to brain, brown fat to control aging in mice

Skeletal muscle signals to brain, brown fat to control aging in mice
The molecule mimecan — released from. Credit: skeletal muscle — helps neurons that activate brown fat maintain the length of their primary cilia (red). Restoring mimecan levels in older mice to that of younger mice helps maintain the length of the cilia and extends lifespan in older mice. Cell nuclei are in blue. Credit: Kentaro Mori

Open lines of communication between the body’s organs are important to health and often falter with age. A new study in mice by researchers at WashU Medicine shows how signals that travel from skeletal muscle to the brain and then activate brown fat and control core body temperature are weakened in elderly mice. The research suggests that finding ways to restore these signals could offer new opportunities to support healthy aging.

The study—led by S...

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Immune cells get transformed into fungus-fighting nanoparticles

Black circular blobs on a gray background.
Transmission electron microscopy image of the antifungal nanodiscs. Image courtesy of Liangfang Zhang lab

Tiny particles made from the membranes of human immune cells could offer a promising new way to fight fungal infections that are becoming harder to treat. Engineers at the University of California San Diego created antifungal nanoparticles that target Candida albicans, a fungus responsible for oral and vaginal yeast infections as well as life-threatening bloodstream infections. In mice with severe Candida infections, the nanoparticles greatly reduced the amount of fungus in major organs and significantly improved survival.

The research, published in Cell Biomaterials, was led by Liangfang Zhang, a professor in the Aiiso Yufeng Li Family Department of Chemical and Nano Engineerin...

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Evidence reveals that the language of thought is not natural language

Separating logic and language
Caption:A functional brain scan of a neurotypical participant in a new study shows a distinct separation between logic (green) and language (red/yellow) activations. Credit: Hope Kean

Some people find it useful to talk through their problems—but language isn’t necessary for logical reasoning, cognitive neuroscientists at MIT’s McGovern Institute for Brain Research say.

In research published in the journal PNAS, researchers led by MIT associate professor of brain and cognitive sciences Evelina Fedorenko have shown that people can perform well on tasks that require logical reasoning even if their language abilities are severely impaired. What’s more, brain imaging shows that language-processing parts of the brain are not called on for logical reasoning.

Philosophers, linguists an...

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Researchers develop ‘hierarchical AI agent’ that tackles complex errands with ease

ETRI develops
Hierarchical AI Agent. Credit: Electronics and Telecommunications Research Institute (ETRI)

Korean researchers have developed a hierarchical AI technology that autonomously plans even complex, long-horizon tasks. The development of this hierarchical task-planning AI technology, which reduces hallucinations and doubles the success rate, is expected to help robots and agents carry out long-term missions.

The Electronics and Telecommunications Research Institute (ETRI) developed the hierarchical task-planning artificial intelligence (AI) technology “ReAcTree,” which autonomously divides tasks requiring complex and lengthy procedures into subgoals and carries them out, and presented it at AAMAS 2026, one of the world’s premier conferences in the AI agent field.

This research achievem...

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