Novel Intestinal Bacterium provides Human gut with Healthy Compounds

The new intestinal bacterium is a member of a newly discovered genus Intestinimonas and is able to efficiently produce butyrate from the amino acid lysine, the most abundant amino acid. Credit: Image courtesy of Wageningen University and Research Centre

Fibers in our food are thought to be good for health since they are converted in the intestinal tract into the favorable compound butyrate, that is crucial to maintain intestinal health. In contrast, protein is believed to be less healthy since intestinal fermentation of amino acids, generates undesired compounds. This latter picture is now changing since a novel intestinal bacterium has been isolated by researchers.

The new intestinal bacterium is a member of a newly discovered genus Intestinimonas and is able to efficiently produce butyrate from the amino acid lysine, the most abundant amino acid. Hence, this bacterium can be considered as a missing link between protein metabolism, butyrate production and health.

Prof Willem M. de Vos’s team studied the genome and its encoded pathways they discovered Intestinimonas to be also capable of generating butyrate from fructoselysine, a potentially harmful Amadori compound that is formed in heated foods from glucose and lysine. It has been estimated that about 10 % of the proteins and peptides that reach the colon every day are Amadori products, ie precursors of glycotoxins or Advanced Glycation Endproducts (AGEs). Diet-derived AGEs have been associated with serious cardiovascular diseases and diabetes, and recently a causal relation has been established in mice between AGEs in foods and dementia.

The discovery of a bacterium capable of producing butyrate from protein, Amadori products and AGEs, will open a new field with attention for protein fermentation instead of the sole focus on sugar degradation from fibers. The team also found that bacteria carrying this novel butyrate-producing pathway are detectable in only some humans, which opens the possibility of targeted approaches to improve gut health in people lacking Intestinimonas or related bacteria. http://www.wageningenur.nl/en/newsarticle/Novel-intestinal-bacterium-provides-human-gut-with-healthy-compounds-.htm