Japanese macaques are exposed to stress during rank fights. Credit: Konstanze Meindl Hightlights: A putative COMT splice mutant (HT3) was associated with increased cortisol excretion. •This haplotype was widely distributed among males. •Cortisol excretion was inversely correlated with physical aggression. •No correlation between cortisol and social rank was found.
Certain genes, such as the COMT gene, are thought to play a role in determining our stress response. Researchers have now studied this gene in macaques, a genus of Old World monkeys, and for the first time have shown that a specific variant of the gene is associated with higher excretion of the stress hormone cortisol. The gene variant may also influence social rank among the animals.
Animals that live in groups face a variety of challenging social situations. The competition for food and mating partners as well as the establishment of the social hierarchy are potential stress factors. “Japanese macaques live in strict hierarchy which entails a high level of aggressive interaction. This makes them ideally suited for a study on stress behaviour,” says Pflüger.
Pflüger, scientific director of the Affenberg facility, studied 26 sexually mature males during the mating season, a particularly stressful time for male animals as they must compete for females. She discovered that the amount of a metabolic product of the hormone cortisol in the animals’ faeces differed across individuals. “The macaques appear to handle stressful situations differently. Some are more courageous than others. We were interested to see whether there were genetic causes for this behaviour and how genetics affects the hormonal stress reaction and social rank,” says Pflüger.
The COMT gene is one of at least 18 genes in humans that control the dopamine system in the brain. Dopamine promotes skills such as planning, decision making and problem solving. Depending on its variant, more or less of the COMT enzyme is produced from the gene, resulting in a faster or slower dopamine metabolization in the brain. Higher amounts of dopamine in the brain increase various cognitive performances but are also associated with increased stress reactions.
Steinborn and Pflüger determined the different variants of the COMT gene in Japanese macaques. This revealed that macaques with high levels of the stress hormone also possess a certain COMT variant that presumably metabolizes dopamine in the brain more slowly. The functionality of this variant and the underlying mechanism resulting in higher stress hormone levels will be determined in further studies. “Our results indicate that animals with stress-resilient COMT variants acquire higher rank positions in the group. But a direct correlation between COMT variant and social rank has to be investigated more closely in the future,” explains Steinborn.
“The dopamine level in the brain controls various behaviours in people. On the one hand, there are the so-called warrior types. In warriors, the dopamine in the brain is metabolized more quickly. Warriors possess lower cognitive skills and are less easily stressed. The 2nd type are worriers, who score higher in cognitive performance tests but are more easily stressed. However, the dopamine system functions like an orchestra and is not dependent on just one factor,” says Steinborn.
In the future, Pflüger and Steinborn want to study other genes that play a role in the dopamine system of non-human primates. They aim to study a variety of primate species with different social styles. Another research focus will be the functionality of the newly discovered COMT gene variant at the RNA and protein levels. http://www.vetmeduni.ac.at/en/infoservice/presseinformation/press-releases-2015/gene-controls-stress-hormone-production-in-macaques/
http://www.sciencedirect.com/science/article/pii/S0018506X15301926
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