Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats. ie AET blunted MI-induced ER stress by reducing protein levels of UPR markers, and accumulation of both misfolded and polyubiquinated proteins, which was associated with restored proteasome activity
Heart failure is a common endpoint for many cardiovascular diseases and is characterized by having reduced cardiac output that leads to dyspnea, exercise intolerance and later death. >20 million people worldwide have heart failure and this will get worse since the prevalence of heart failure will rise as the mean age of the population increases.
Despite heart failure seems to be a multifactorial syndrome, a common point observed by several studies was the accumulation of misfolded proteins in cardiac cells of both humans and animals with heart failure.
In the current study from K. G. Jebsen – Center of Exercise in Medicine at the Norwegian University of Science and Technology (NTNU) in collaboration with Professor Patricia Brum’s research group at University of Sao Paulo, Luiz Bozi and colleagues discovered misfolded protein accumulation in a rat model of heart failure was related to disruption of the cardiac protein quality control system. Since there is no pharmacology therapy targeting the protein quality control system, Luiz Bozi and colleagues investigated whether aerobic exercise training, an efficient therapy for prevention and treatment of a variety of cardiovascular diseases, would reestablish the cardiac protein quality control system and improve cardiac function of heart failure rats.
In fact, they verified that aerobic exercise training restored the cardiac protein quality control system, which was related to reduced misfolded protein accumulation and improved cardiac function in heart failure animals. These results suggest that heart failure development is associated with disruption of cardiac protein quality control system and reinforce the importance of aerobic exercise training as a primary non-pharmacological therapy for treatment of heart failure patients. http://www.eurekalert.org/pub_releases/2016-07/nuos-eti070816.php
http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12894/abstract
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