University of Iowa researchers have found that the gut may be key to preventing Parkinson’s disease. Cells located in the intestine spark an immune response that protects nerve cells, or neurons, against damage connected with Parkinson’s disease. Acting like detectives, the immune intestinal cells identify damaged machinery within neurons and discard the defective parts. That action ultimately preserves neurons whose impairment or death is known to cause Parkinson’s. Credit: Veena Prahlad, University of Iowa
Your gut may be key to preventing Parkinson’s disease. Cells in the intestine spark an immune response that protects nerve cells, or neurons, against damage connected with Parkinson’s disease. These immune intestinal cells identify damaged machinery within neurons and discard the defective parts which preserves neurons whose impairment or death is known to cause Parkinson’s. “We think somehow the gut is protecting neurons,” says Veena Prahlad, assistant professor in biology at the UI.
Parkinson’s disease affects some 500,000 people in the U.S., according to the National Institutes of Health. Neural dopamine shortage causes the motor-control problems associated with the disease. Scientists have previously linked Parkinson’s to defects in mitochondria. Some think the impaired mitochondria starve neurons of energy; others believe they produce a neuron-harming molecule. Whatever the answer, damaged mitochondria have been linked to other nervous disorders as well, including ALS and Alzheimer’s, and researchers want to know why.
Prahlad’s team exposed roundworms to a poison called rotenone, which researchers know kills neurons whose death is linked to Parkinson’s. As expected, the rotenone began damaging the mitochondria in the worms’ neurons. To the researchers’ surprise though, the damaged mitochondria did not kill all of the worms’ dopamine-producing neurons; in fact, over a series of trials, only 7% of the worms, roughly 210 out of 3,000, lost dopamine-producing neurons when given the poison.
It turns out roundworms’ immune defenses, activated when the rotenone was introduced, discarded many of the defected mitochondria, halting a sequence that would’ve led to the loss of dopamine-producing neurons. Importantly, the immune response originated in the intestine, not the nervous system. The researchers plan to conduct more experiments, but they’ve got some interesting hypotheses. One is the intestinal immune cells are, according to Prahlad, “constantly surveilling mitochondria for defects.”
Even more, those cellular watchdogs may be keeping their eyes on the mitochondria “because they don’t trust them,” Prahlad suggests. The reason has to do with the prevailing theory that mitochondria originated independently as a type of bacterium and were only later incorporated into the cells of animal, plants, and fungi as an energy producer. If that theory is correct, the intestinal immune responders may be especially sensitive to changes in mitochondrial function not only for its potential damaging effects, but because of the mitochondria’s ancient and foreign past as well.
“How it’s happening is suggestive of the possibility that the innate immune response is constantly checking its mitochondria,” Prahlad says, “perhaps because of the bacterial origin of the mitochondria.” https://now.uiowa.edu/2016/09/parkinsons-disease-protection-may-begin-gut
http://dx.doi.org/10.1016/j.celrep.2016.07.077
Recent Comments