Category Biology/Biotechnology

Study finds Dopamine Regulates How Quickly and Accurately Decisions are made

Dopamine regulates how quickly and accurately decisions are made
Behavioral data. Response time (RT) distributions (n = 31, within-subject design) under Placebo (a), L-dopa (b), and Haloperidol (c). Choices of the suboptimal (20% reinforced) options in (a–c) are coded as negative RTs, whereas choices of the optimal (80% reinforced) options are coded as positive RTs. d Accuracy per drug condition (chance level is 0.5). e Total rewards earned per condition. f Median RT per drug condition. Pl – Placebo, L – L-dopa, H – Haloperidol. For boxplots, lines represent the median, the box covers the upper and lower quartiles, and the whiskers denote the range of datapoints falling within 1.5 times the interquartile range. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-41130-y

A recent study provides new insight into the relat...

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Mature Sperm Lack Intact Mitochondrial DNA

Sperm TFAM relocalization during spermatogenesis.

New research provides insight about the reason mitochondria — the powerhouse of the cell — pass only from the mother. Scientists have long recognized the fact that mitochondrial DNA, or mtDNA, comes exclusively from egg cells in humans, meaning only the mother contributes the genetic code carried by thousands of mitochondria necessary for energy production in every cell in the body.

Previously, it was believed that paternal mtDNA was eliminated soon after a sperm fuses with an oocyte, or developing egg, during fertilization, possibly through an immune-like search-and-destroy response.

However, the study found that while mature sperm do carry a small number of mitochondria, they lack intact mtDNA.

“We found that each sperm cell ...

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Gene Links Exercise Endurance, Cold Tolerance, and Cellular Maintenance in Flies

flies moving sled in snow with person
Jacob Dwyer, Michigan Medicine

The gene, dubbed Iditarod, seems responsible for exercise’s ability to clean up damaged cells. As the days get shorter and chillier in the northern hemisphere, those who choose to work out in the mornings might find it harder to get up and running. A new study in PNAS identifies a protein that, when missing, makes exercising in the cold that much harder – that is, at least in fruit flies.

A team from University of Michigan Medical School and Wayne State University School of Medicine discovered the protein in flies, which they named Iditarod after the famous long distance dog sled across Alaska, while studying metabolism and the effect of stress on the body.

They were particularly interested in a physiological process called autophagy wherein damaged...

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Parker Probe observes Powerful Coronal Mass Ejection ‘Vacuum up’ Interplanetary Dust

In black and white, a cloud from a CME pushes the bright speckles of dust out of the way, leaving a screen of near darkness.
Parker Solar Probe’s Wide Field Imagery for Solar Probe (WISPR) camera observes as the spacecraft passes through a massive coronal mass ejection on Sept. 5, 2022. Coronal mass ejections are immense eruptions of plasma and energy from the Sun’s corona that drive space weather.
Credit: NASA/Johns Hopkins APL/Naval Research Lab

On Sept. 5, 2022, NASA’s Parker Solar Probe soared gracefully through one of the most powerful coronal mass ejections (CMEs) ever recorded—not only an impressive feat of engineering, but a huge boon for the scientific community. Parker’s journey through the CME is helping to prove a 20-year-old theory about the interaction of CMEs with interplanetary dust, with implications for space weather predictions...
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