Category Biology/Biotechnology

The lifespan of a small roundworm that has been used as a key model organism in ageing research is limited by how it self-sacrifices to feed its young, finds a new study led by UCL researchers.

The authors of the new Nature Communications paper say their findings raise questions about how well insights from the Caenorhabditis elegans (C. elegans) worm can be translated to human ageing advances.

C. elegans is widely used as a laboratory animal, and has been central to ageing research for 40 years thanks to discoveries of genes that can be supressed to produce up to a tenfold increase in the worm’s lifespan.

The UCL research team investigated what drives the lifespan of C...

Scientists discover role immune system’s T cells play in regulating fat and muscle loss during infection in mice. Scientists discovered that 1) the wasting response to T. brucei infection in mice occurs in two phases, each regulated by different immune cells and 2) fat loss did not benefit the fight against infection, but muscle loss did. The findings inform the development of more effective therapeutics that spare people from wasting and increase our understanding of how wasting influences survival and morbidity across infections, cancers, chronic illnesses, and more.

Although infections can present with many different symptoms, one common symptom is the loss of fat and muscle, a proc...

Shifting from a high-pressure mindset to a curious one improves people’s memory.

New research from Duke found that people who imagined being a thief scouting a virtual art museum in preparation for a heist were better at remembering the paintings they saw, compared to people who played the same computer game while imagining that they were executing the heist in-the-moment.

These subtle differences in motivation—urgent, immediate goal-seeking versus curious exploration for a future goal—have big potential for framing real-world challenges such as encouraging people to get a vaccine, prompting climate change action, and even treating psychiatric disorders.

The findings appeared online July 25 in the Proceedings of the National Academy of Sciences.

Alyssa Sinclair, Ph.D...

University of Virginia School of Medicine researchers have discovered a key driver of chronic inflammation that accelerates aging, a finding that could lead to longer, healthier lives and the possible prevention of age-related conditions such as deadly heart disease and devastating brain disorders.

The harmful inflammation is driven by improper calcium signaling in the mitochondria of certain immune cells, researchers found. Mitochondria are the power generators in all cells, and they rely heavily on calcium signaling.

The UVA Health res...