Category Biology/Biotechnology

Researchers reveal how Cells Rewrite their Fate

Researchers reveal how cells rewrite their fate
C/EBPαR35A interacts more strongly with PU.1 than unmated C/EBPα, shown here by an assay that scores the proximity of antibodies against the two proteins. Credit: Thomas Graf/Centre for Genomic Regulation

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association in Berlin have revealed how cells accelerate changes to their identity, a process known as cell fate conversion.

The study, published today in the journal eLife, has implications for cancer research as the disease often arises from errors in cell fate decisions. The study could eventually lead to new methods of accelerating or manipulating the molecular mechanisms involved in the formation of cancer.

Central to the study is C/EBPα...

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Grocery Store Carts set to help Diagnose common Heart Rhythm Disorder and Prevent Stroke

Supermarket trolleys with ECG sensors can help prevent stroke risk: Study
Supermarket trolleys, equipped with electrocardiogram (ECG) sensors, may help diagnose atrial fibrillation – which can then be treated to prevent disabling or fatal strokes.

It could be the shopping trip that saves your life: supermarket trolleys are helping to diagnose atrial fibrillation which can then be treated to prevent disabling or fatal strokes. The research is presented today at ACNAP 2023, a scientific congress of the European Society of Cardiology (ESC).

“This study shows the potential of taking health checks to the masses without disrupting daily routines,” said study author Professor Ian Jones of Liverpool John Moores University, UK. “Over the course of two months, we identified 39 patients who were unaware that they had atrial fibrillation...

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New Research Clarifies Connection Between Autism and the Microbiome

The biological roots of autism continue to perplex researchers, despite a growing body of studies looking at an increasing array of genetic, cellular and microbial data. Recently, scientists have homed in on a new and promising area of focus: the microbiome. This collection of microbes that inhabit the human gut has been shown to play a role in autism, but the mechanics of this link have remained awash in ambiguity.

Taking a fresh computational approach to the problem, a study published today, June 26, in Nature Neuroscience sheds new light on the relationship between the microbiome and autism...

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Researchers find a New Class of Biomarkers to Predict Treatment Outcomes in Cancer Patients

Researchers find a new of biomarkers to predict treatment outcomes in cancer patients
Cancer is the result of the uncontrolled division and spread of cells into surrounding tissue. Recently researchers have begun to focus on biomarkers as a source of information about different cancers, how they work in the body, and how they can be fought. Credit: Colin Behrens/Pixabay, CC0 Public Domain

One of the big reasons that cancer is difficult to treat is that patients respond to treatments differently, and these differences can rarely be anticipated. In most cases, determining whether and how a patient will respond to any given therapy requires administering it to the patient and then waiting and watching. That is a lot of pressure for researchers and physicians and a lot of risk for cancer patients, and added expense.

If a patient’s response were predictable, optimal thera...

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