Category Biology/Biotechnology

NAD⁺ restores memory in Alzheimer’s disease models by correcting RNA errors

NAD⁺ restores memory in Alzheimer's' disease models by correcting RNA errors
NR induces transcription of genes involved in axon development, oxygen metabolism, mitochondrion localization, and autophagy in tauopathy mice. GO terms enriched in each of the eight classes of clusters in (A); each circular bar graph represents one cluster or class of clusters, and bar length correlates with the number of DEGs represented. GO terms shown in red font relate to mRNA. Clusters 4 and 5 are similar and are grouped together. Class 1 includes clusters 1, 2, and 6 marked with red. Class 2 includes clusters 4 and 5 marked with orange. Class 3 includes cluster 8 marked with yellow. GTPase, guanosine triphosphatase; NAD(P)H, reduced form of NAD phosphate; IRES, internal ribosomal entry site; GTP, guanosine 5′-triphosphate; MHC, major histocompatibility complex. Credit: Science A...
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A little-known desert berry may hold the key to fighting diabetes

Scientists may have uncovered a surprising new weapon in the fight against diabetes: the fruit of an ancient desert plant. Known as Nitraria roborowskii Kom, this resilient shrub has long been used in traditional medicine but has only recently gained scientific attention. In modern experiments, its fruit extract displayed a remarkable ability to reverse insulin resistance and restore healthy metabolism in diabetic mice.

The results went far beyond stabilizing blood sugar. Researchers found that the extract also corrected lipid imbalances and reduced oxidative stress, two major complications of diabetes. These effects were linked to the activation of a key cellular signaling pathway that helps regulate metabolism...

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Urolithin A nudges aging immune cells toward a youthful profile in 28 days

Urolithin A nudges aging immune cells toward a youthful profile in 28 days
Secondary end point—UA alters inflammatory immune response. Credit: Nature Aging (2025). DOI: 10.1038/s43587-025-00996-x

An international research team focused on aging reports that urolithin A at 1,000 mg per day shifted human immune profiles toward a more naive-like, less exhausted CD8+ state and increased fatty acid oxidation capacity, with additional functional gains.

Urolithin A is a metabolite produced by gut bacteria after breaking down ellagic acid from certain foods, such as pomegranates and walnuts. While produced naturally through microbial digestion, it is in much smaller quantities than available as a supplement or used in the study.

Aging bodies face reduced production of mature T cells, shrinking naive T cell pools and chronic low-grade inflammation...

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Rebalancing the Gut: How AI Solved a 25-Year Crohn’s Disease Mystery

Graphic of macrophages
Electron micrographs show how macrophages expressing girdin neutralize pathogens by fusing phagosomes (P) with the cell’s lysosomes (L) to form phagolysosomes (PL), compartments where pathogens and cellular debris are broken down (left). This process is crucial for maintaining cellular homeostasis. In the absence of girdin, this fusion fails, allowing pathogens to evade degradation and escape neutralization (right). (UC San Diego Health Sciences)

AI uncovers how a severed bond between two gut proteins sparks Crohn’s disease, and how restoring it could heal inflammation. UC San Diego researchers combined artificial intelligence with molecular biology to unravel how immune cells in the gut decide between inflammation and healing, a process gone awry in Crohn’s disease...

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