Category Biology/Biotechnology

Preclinical Data suggest Antioxidant Strategy to address Mitochondrial Dysfunction caused by SARS-CoV-2 virus

SARS-CoV-2
Credit: Unsplash/CC0 Public Domain

Building upon groundbreaking research demonstrating how the SARS-CoV-2 virus disrupts mitochondrial function in multiple organs, researchers from Children’s Hospital of Philadelphia (CHOP) demonstrated that mitochondrially-targeted antioxidants could reduce the effects of the virus while avoiding viral gene mutation resistance, a strategy that may be useful for treating other viruses.

The preclinical findings were published in the journal Proceedings of the National Academy of Sciences.

Last year, a multi-institutional consortium of researchers found that the genes of the mitochondria, the energy producers of our cells, can be negatively impacted by the virus, leading to dysfunction in multiple organs beyond the lungs.

SARS-CoV-2 proteins can...

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Neural Networks Made of Light

Artistic illustration of a neuromorphic system of waveguides carrying light.© Clara Wanjura

Scientists propose a new way of implementing a neural network with an optical system which could make machine learning more sustainable in the future. The researchers at the Max Planck Institute for the Science of Light have published their new method in Nature Physics, demonstrating a method much simpler than previous approaches.

Machine learning and artificial intelligence are becoming increasingly widespread with applications ranging from computer vision to text generation, as demonstrated by ChatGPT. However, these complex tasks require increasingly complex neural networks; some with many billion parameters...

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Scorching Storms on Distant Worlds Revealed

brown dwarf
Artist’s impression of the nearest brown dwarf to Earth. Credit – ESO/I. Crossfield/N. Risinger.

Astronomers have created the most detailed weather report so far for two distant worlds beyond our own solar system. Astronomers have created the most detailed weather report so far for two distant worlds beyond our own solar system.

The international study — the first of its kind — reveals the extreme atmospheric conditions on the celestial objects, which are swathed in swirling clouds of hot sand amid temperatures of 950C.

Using NASA’s powerful James Webb Space Telescope (JWST), researchers set out to capture the weather on a pair of brown dwarfs — cosmic bodies that are bigger than planets but smaller than stars.

These brown dwarfs, named collectively as WISE 1049AB, are the bri...

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Researchers Pinpoint Brain Cells that Delay First Bite of Food

A set of neurons identified by Scripps Research scientists influence the start of eating and drinking. Do you grab a fork and take a first bite of cake, or say no and walk away? Our motivation to eat is driven by a complex web of cells in the brain that use signals from within the body, as well as sensory information about the food in front of us, to determine our behaviors. Now, Scripps Research scientists have identified a group of neurons in a small and understudied region of the brain — the parasubthalamic nucleus (PSTN) — that controls when an animal decides to take a first bite of food.

In the study, published in Molecular Psychiatry on July 4, 2024, the team of scientists set out to selectively manipulate a group of PSTN cells that dial up their activity during periods of bi...

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