Category Biology/Biotechnology

Spike Mutations that Help SARS-CoV-2 Infect the Brain Discovered

SARS-CoV-2 , COVID-19
Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID

Scientists have discovered a mutation in SARS-CoV-2, the virus that causes COVID-19, that plays a key role in its ability to infect the central nervous system. The findings may help scientists understand its neurological symptoms and the mystery of “long COVID,” and they could one day even lead to specific treatments to protect and clear the virus from the brain.

The new collaborative study between scientists at Northwestern University and the University of Illinois-Chicago uncovered a series of mutations in the SARS-CoV-2 spike protein (the outer part of the virus that help...

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Gut Bioelectricity provides a Path for ‘Bad’ Bacteria to Cause Diseases

The electrical field-guided migration of S. Typhimurium as shown by immunostaining

Study discovers an electric current in the gut that attracts pathogens like Salmonella. Researchers have discovered a novel bioelectrical mechanism that pathogens like Salmonella use to find entry points in the gut lining that would allow pathogens to pass and cause infection.

How do bad bacteria find entry points in the body to cause infection?

This question is fundamental for infectious disease experts and people who study bacteria. Harmful pathogens, like Salmonella, find their way through a complex gut system where they are vastly outnumbered by good microbes and immune cells. Still, the pathogens navigate to find vulnerable entry points in the gut that would allow them to invade and infect the body.

A team of UC Davis Health researchers has discovered a novel bioelectric...

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Gut Microbial Pathway identified as Target for Improved Heart Disease Treatment

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Topological designation of the secondary structure of β2AR. The figure displays the overlap of the secondary structures of the 4 crystal structures of β2AR used in this study.

Cleveland Clinic researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease. The study published in Nature Communications found that phenylacetylglutamine (PAG), produced by gut bacteria as a waste product, then absorbed and formed in the liver, interacts with previously undiscovered locations on beta-2 adrenergic receptors on heart cells once it enters the circulation.

PAG was shown to interact with beta-2 adrenergic receptors to influence how forcefully the heart muscle cells contract—a process that investigators believe contributes to he...

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Improving Access to Heart-Failure Screening with Saliva

Spit to save lives: 15-minute saliva test detects heart failure at home
A new saliva-based test for heart failure measures two biomarkers from a drop of saliva in about 15 minutes and can be administered at home.

Heart failure is a leading cause of death worldwide and is especially deadly for people who don’t have access to medical facilities. A team of researchers aims to bring heart failure screening from the lab to the home with a point-of-care electrochemical biosensor prototype that measures levels of two biomarkers for heart failure in as little as 15 minutes from just a drop of saliva.

Trey Pittman, a graduate student at Colorado State University, will present his team’s research at the fall meeting of the American Chemical Society (ACS).

“Our device would be ideal for people who are at high risk for heart failure but have limited access to a ...

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