Category Biology/Biotechnology

Epstein-Barr Virus and Brain Cross-reactivity: Possible mechanism for Multiple Sclerosis detected

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Source: NIAID
An electron micrograph showing three Epstein-Barr virus (EBV) particles colorized red-orange.

The role that Epstein-Barr virus (EBV) plays in the development of multiple sclerosis (MS) may be caused by a higher level of cross-reactivity, where the body’s immune system binds to the wrong target, than previously thought.

In a new study published in PLOS Pathogens, researchers looked at blood samples from people with MS, as well as healthy people infected with EBV and people recovering from glandular fever caused by recent EBV infection.

The study investigated how the immune system deals with EBV infection as part of worldwide efforts to understand how this common virus can lead to the development of multiple sclerosis, following 20 years of mounting evidence showing a...

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Researchers Unveil Pioneering Approach to Combat Age-Related Vision Loss

Cirrus Therapeutics, the University of Bristol, and London’s Global University Institute of Ophthalmology have discovered a new treatment for age-related macular degeneration (AMD), the leading cause of vision loss among older adults.

Featured on the cover of the journal Science Translational Medicine, this research reveals that boosting a specific protein, IRAK-M, in retinal cells could offer a new and highly effective therapy for AMD.

AMD can severely impact a person’s vision. Patients suffering from AMD often start with blurred vision or seeing a black dot in their central vision, which can ultimately expand to the point where there is no useful central vision...

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First Step in Allergic Reactions, Paving the way for New Preventative Strategies

Scientists at Duke-NUS Medical School have identified how the first domino falls after a person encounters an allergen, such as peanuts, shellfish, pollen or dustmites. Their discovery, published in the April issue of Nature Immunology, could herald the development of drugs to prevent these severe reactions.

It is well established that when mast cells, a type of immune cell, mistake a harmless substance, such as peanuts or dust mites, as a threat, they release an immediate first wave of bioactive chemicals against the perceived threat...

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Researchers discover ‘Trojan Horse’ Virus Hiding in Human Parasite

Apocryptovirus odysseus (Ao) genome. From (rnaspades 3.15.5) assembly of the Ngô RNA sequencing dataset (SRR1205923), we recovered a high-coverage (123× coverage) RdRp-encoding contig, and identified a second correlated contig of likely viral origin. Contig 2 (279× coverage) contains two putative ORFs: pORF1 and pORF2, but these ORFs do not have identifiable homologs via BLASTp in the non-redundant and transcriptome shotgun assembly databases (date accessed: June 2023), TBLASTN with the nucleotide database, or by InterProScan or HHpred (date accessed: June 2023). Inlay, unbranched assembly graphs (Bandage 0.8.1) of both contigs confirmed a linear genome structure.
Apocryptovirus odysseus (Ao) genome. From (RNASPADES 3.15.5) assembly of the Ngô RNA sequencing dataset (SRR1205923), we recovered a high-coverage (123× coverage) RdRp-encoding contig, and identified a second correlated contig of likely viral origin. Contig 2 (279× coverage) contains two putative ORFs: pORF1 and pORF2, but these ORFs do not have identifiable homologs via BLASTp in the non-redundant and transcriptome shotgun assembly databases (date accessed: June 2023), TBLASTN with the nucleotide database, or by InterProScan or HHpred (date accessed: June 2023). Inlay, unbranched assembly graphs (Bandage 0.8.1) of both contigs confirmed a linear genome structure.

An international team led by researchers at the University of Toronto has found a new RNA virus that they believe is h...

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