Category Biology/Biotechnology

Newly discovered brain cells count each bite before sending the order to cease eating a meal. Columbia scientists have found specialized neurons in the brains of mice that order the animals to stop eating.

Though many feeding circuits in the brain are known to play a role in monitoring food intake, the neurons in those circuits do not make the final decision to cease eating a meal.

The neurons identified by the Columbia scientists, a new element of these circuits, are located in the brainstem, the oldest part of the vertebrate brain. Their discovery could lead to new treatments for obesity.

“These neurons are unlike any other neuron involved in regulating satiation,” says Alexander Nectow, a physician-scientist at Columbia University Vagelos College of Physicians and Surgeons...

ETH researchers have developed a new gene switch that can be activated using a commercially available nitroglycerine patch applied to the skin. One day, researchers want to use switches of this kind to trigger cell therapies for various metabolic diseases.

The body regulates its metabolism precisely and continuously, with specialized cells in the pancreas constantly monitoring the amount of sugar in the blood, for example. When this blood sugar level increases after a meal, the body sets a signal cascade in motion in order to bring it back down.

In people suffering from diabetes, this regulatory mechanism no longer works exactly as it should...

Who hasn’t been there? The big meal is over, you’re full, but the craving for sweets remains. Researchers from the Max Planck Institute for Metabolism Research have now discovered that what we call the “dessert stomach” is rooted in the brain. The same nerve cells that make us feel full after a meal are also responsible for our craving for sweets afterwards.

To find the cause of the “dessert stomach,” the researchers investigated the reaction of mice to sugar and found that completely satiated mice still ate desserts. The paper is published in the journal Science.

Investigations of the brain showed that a group of nerve cells, the so-called POMC neurons, are responsible for this...

Every year, more than 5 million people in the U.S. are diagnosed with heart valve disease, but this condition has no effective long-term treatment. When a person’s heart valve is severely damaged by a birth defect, lifestyle, or aging, blood flow is disrupted. If left untreated, there can be fatal complications.

Valve replacement and repair are the only methods of managing severe valvular heart disease, but both often require repeated surgeries that are expensive, disruptive, and life-threatening. Most replacement valves are made of animal tissue and last up to 10 or 15 years before they must be replaced...