Category Health/Medical

New Alzheimer’s Disease Pathways identified

New Alzheimer's disease pathways identified
Path model of main findings. This path model summarizes the main-effect mediation model. Circles indicate principal components or latent variables, rectangles represent observed variables. Arrows either indicate PC loadings or structural regression paths. Thicker lines correspond to stronger loadings, solid structural paths are genome-wide significant (p < 5 × 10−8), and dashed lines are suggestive (p < 0.008). Coefficients indicate either the effect of one effect allele on a biomarker PC in SD, or the effect of one SD higher biomarker PC score on latent AD in SD. Note: all paths are adjusted for assessment age, sex, genetic ancestry, and study but are omitted from figure. Credit: Genome Medicine (2023). DOI: 10.1186/s13073-023-01233-z

Dementia, which includes Alzheimer’...

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New Wound Healing Research Produces Full Thickness Human Bioprinted Skin

Wound healing
WFIRM researchers use cells and hydrogels as bioinks to 3D print human skin.
CREDIT
Wake Forest Institute for Regenerative Medicine

A research paper published today in Science Translational Medicine presents a significant breakthrough in the area of skin regeneration and wound healing by researchers at the Wake Forest Institute for Regenerative Medicine (WFIRM). The study, titled “Bioprinted Skin with Multiple Cell Types Promotes Skin Regeneration, Vascularization, and Epidermal Rete Ridge Formation in Full-Thickness Wounds,” shows the successful development of bioprinted skin that accelerate wound healing, support healthy extracellular matrix remodeling, and provide optimism for complete wound recovery. Anthony Atala, M.D., director of WFIRM and Adam Jorgensen, M.D., Ph.D...

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Allergy Study on ‘Dirty’ Mice Challenges the Hygiene Hypothesis

mice
Credit: CC0 Public Domain

The notion that some level of microbial exposure might reduce our risk of developing allergies has arisen over the last few decades and has been termed the hygiene hypothesis.

Now, an article published in Science Immunology by researchers from Karolinska Institutet challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than “clean” laboratory mice.

How microbes may prevent allergy has been a topic of great interest in recent times. Studies have suggested that certain infections might reduce the production of inflammatory antibodies to allergens and alter the behavior of T cells involved in allergies...

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Experimental Nasal Spray may offer Quick, Easy Remedy for Treating Rapid Heartbeat

Heart chambers illustration
Heart chambers illustration
4 chambers of the heart: right atrium, right ventricle, left atrium, left ventricle.
Watch, Learn, and Live Library
copyright American Heart Association

In a new study, etripamil, a rapid- and short-acting investigational medication formulated to be delivered via nasal spray, restored a normal heart rhythm in less than 30 minutes in most users with intermittent rapid heartbeats, sparing them a trip to the emergency room to receive intravenous medication.

A fast-acting medication delivered as a nasal spray may someday allow patients with intermittent rapid heartbeats to treat it themselves as soon as they develop symptoms, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the A...

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