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    Category Health/Medical

    Whether Physical Exertion feels ‘Easy’ or ‘Hard’ may be due to Dopamine levels, study suggests

    April 17, 2023, Categories  Biology/Biotechnology, Health/Medical

    Experimental paradigm. a Association phase; Participants were trained to associate between grip force exerted on a handheld dynamometer and effort levels from 0 to 100 (80% of maximum voluntary contraction (MVC)). Each trial began with presentation of the target, followed by an effortful grip with real-time visual feedback of the exerted force represented as a bar that increased in height with increased exertion. A target zone was also presented, and participants were asked to maintain their exerted force within this target zone. The target zone turned green when exerted force was within the target and stayed red otherwise. Feedback of success or failure was provided at the end of each trial...
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    Probiotic company finds Links between Youthful Gut Microbiota and Potential Centenarians

    April 13, 2023, Categories  Biology/Biotechnology, Health/Medical

    Probiotic company finds links between youthful gut microbiota and potential centenarians
    Comparisons of microbial compositions between baseline and follow-up. (a) aPCoA of the Bray‒Curtis distance plot for baseline and follow-up after adjusting for hypertension, medication use, and alcohol and tea drinking. (b) α-Diversity differences between baseline and follow-up for stratified health statuses (HB, n = 21; HF, n = 15; LHB, n = 19; LHF, n = 27). (c) Composition of the gut microbiome at the phylum level between baseline and follow-up for stratified health statuses. (d) LEfSe between baseline and follow-up stratified by health status (two-sided Kruskal‒Wallis test between classes; P < 0.05, LDA > 2). Healthy baseline (HB, n = 21), healthy follow-up (HF, n = 15), less healthy baseline (LHB, n = 19) and less healthy follow-up (LHF, n = 27) samples were examined...
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    Novel Immunotherapy Agent Safe, shows promise against High-risk Prostate Cancers

    April 12, 2023, Categories  Biology/Biotechnology, Health/Medical

    Shenderov
    Prostate cancer nodule with dramatized anti-B7-H3 antibody therapy Credit: Adobe stock per investigator

    A new drug, a monoclonal antibody known as enoblituzumab, is safe in men with aggressive prostate cancer and may induce clinical activity against cancer throughout the body, according to a phase 2 study led by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. If confirmed in additional studies, enoblituzumab could become the first promising antibody-based immunotherapy agent against prostate cancer.

    In a clinical trial, 32 men with high-risk or very high-risk prostate cancers who were scheduled for prostate cancer surgery were treated with six weekly infusions of enoblituzumab prior to surgery, and were followed fo...

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    Study shows how to Prevent a High-fat Diet from throwing Metabolism out of whack

    April 10, 2023, Categories  Biology/Biotechnology, Health/Medical

    Study shows how to prevent a high-fat diet from throwing metabolism out of whack
    SAPS3 brings the PP6 catalytic subunit to dephosphorylate AMPK. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-36809-1

    Eating lots of fats increases the risk of metabolic disorders, but the mechanisms behind the problem have not been well understood. Now, University of California, Irvine biologists have made a key finding about how to ward off harmful effects caused by a high-fat diet. Their study appears in Nature Communications.

    The UC Irvine research centered on a protein complex called AMPK, which senses the body’s nutrition and takes action to keep it balanced. For example, if AMPK detects that glucose is low, it can boost lipid breakdown to produce energy in its place...

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