Category Health/Medical

‘Smart’ Bandages Monitor Wounds and provide Targeted Treatment

A larger version of the smart bandage rests on the back of a gloved hand
A larger version of the smart bandage.

Researchers have developed a flexible electronic bandage for use on chronic wounds, particularly in diabetic patients. The bandage monitors signs of inflammation, collecting medical data, providing medication as needed and stimulate tissue growth.

These kinds of chronic wounds are not just debilitating for the people suffering from them. They are also a drain on healthcare systems, representing a $25 billion financial burden in the United States alone each year.

A new kind of smart bandage developed at Caltech may make treatment of these wounds easier, more effective, and less expensive...

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Researchers discover a way to Fight the Aging Process and Cancer Development

Microscope image of C. elegans 10 days after treatment with UV-B rays. Left: Worms with intact DREAM complex cannot repair DNA well. Right: Worms without DREAM complex repair damage and live longer.

The DREAM protein complex prevents the repair of genome damage in human cells, in mice and in the nematode Caenorhabditis elegans, a team of researchers at the University of Cologne has discovered. They also successfully inhibited this complex for the first time using a pharmaceutical agent.

“When we suppress the so-called DREAM complex in body cells, various repair mechanisms kick in, making these cells extremely resilient towards all kinds of DNA damage,” said Professor Dr Björn Schumacher, Director of the Institute for Genome Stability in Aging and Disease at the University of Cologne...

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Patient-specific Cells Generated from Thymus Organoids

Figure thumbnail gr1
Generation of hPSC-derived TECs in vitro
(A) Schematic of TEP-only sTOs.
(B) Representative IF images of KRT8 (green) and KRT5 (magenta) in day 16–22 TEPs and week 2 TEP-only sTOs (TEPs, n = 2 indepdendent experiment (ind. exp.), 2 hPSC lines; sTOs, n = 3 ind. exp., 2 hPSC lines).
(C–H) FC plots and quantification of EPCAM/HLA-DR (C and D), EPCAM/CD205 (E and F), and EPCAM/GFP (G and H) expression in day 16–22 TEPs and week 2 TEP-only sTOs.
(I) tSNE plots of EPCAM, HLA-DR, CD205, and GFP expression in 16–22 TEPs and week 2 TEP-only sTOs, n = 3 ind. exp., 1 hPSC line.
Plots show percentage of the mean; data are shown as mean Â±
± SEM.

Researchers have used pluripotent stem cells to make thymus organoids that support the development of patient-specific T cells, researchers report Marc...

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A Plant-based Compound that Inhibits Reactivation of HIV viral Reservoir, giving the Immune System a break

Researchers identify a plant-based compound that inhibits reactivation of the HIV viral reservoir, giving the immune system a br
Overview of HIV inhibitor screening strategy and identification of (–)-hopeaphenol. (A) Representative flow cytometry examples of HIV-GFP reporter expression in unstimulated live J-Lat 9.2 cells treated with 0.1% DMSO control (left), live cells stimulated to express HIV-GFP by 0.1 μg/mL of the control latency-reversing agent PMA (center), and suppression of PMA-induced virus expression in live cells by 10 μM hopeaphenol (right); (B) chemical structure of (–)-hopeaphenol; (C) effects of hopeaphenol on PMA-induced HIV production in J-Lat 9.2 cells. Blue dotted line denotes half-maximal inhibition. In panel C, results denote the mean ± SD from three independent experiments. Credit: Antimicrobial Agents and Chemotherapy (2023). DOI: 10.1128/aac.01600-22

As of 2022, approximately...

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