Category Health/Medical

A research team has identified different subtypes of white matter (WM) astrocytes, including a unique type with the ability to multiply and potentially aid in brain repair. Using single-cell RNA sequencing and spatial transcriptomics, the scientists mapped astrocyte diversity across different brain regions and species, providing the first detailed molecular profile of WM astrocytes.

The team was led by Dr. Judith Fischer-Sternjak from Helmholtz Munich and Ludwig-Maximilians-Universität (LMU) München, alongside Prof. Magdalena Götz from Helmholtz Munich, LMU and the Munich Cluster for Systems Neurology (SyNergy)...

Researchers used visual threat manipulation in the virtual reality environment and thermal stimulation to investigate how the brain perceives pain. They found that the brain perceives pain more strongly when the perceived pain is out of alignment with reality. In particular, pain was amplified when unexpected events occurred.

Pain perception can vary greatly. Sometimes, we feel pain more intensely than expected due to an injury or physical ailment but may feel less intense pain at other similar instances. This variability indicates that our perception of pain is highly dependent on our expectations and uncertainty.

Two hypotheses have been proposed to explain how the brain perceives pain.

One is the Estimate Hypothesis, where the brain estimat...

Acting in the right place at the right time is the key to effective medical treatment with minimal side effects. However, this feat remains difficult to achieve. Biologists and chemists at the University of Geneva (UNIGE) have succeeded in developing a tool that controls the location at which a molecule is activated by a simple pulse of light lasting only a few seconds. Tested on a protein essential for cell division, this system could be applied to other molecules. The potential applications are vast, both in basic research and in improving existing medical treatments, such as those for skin cancer. These results are published in the journal Nature Communications.

Regardless of how it is administered, a medication does not only act on the organ affected but has a systemic effect o...

Newly discovered brain cells count each bite before sending the order to cease eating a meal. Columbia scientists have found specialized neurons in the brains of mice that order the animals to stop eating.

Though many feeding circuits in the brain are known to play a role in monitoring food intake, the neurons in those circuits do not make the final decision to cease eating a meal.

The neurons identified by the Columbia scientists, a new element of these circuits, are located in the brainstem, the oldest part of the vertebrate brain. Their discovery could lead to new treatments for obesity.

“These neurons are unlike any other neuron involved in regulating satiation,” says Alexander Nectow, a physician-scientist at Columbia University Vagelos College of Physicians and Surgeons...