Category Health/Medical

A hidden “backup heater” that helps burn fat and boost metabolism

Weisensee Lab

Scientists at Washington University School of Medicine in St. Louis have uncovered a new way that brown fat, a type of fat that burns energy, can boost the body’s metabolism. This process allows cells to consume more fuel and generate heat, improving overall metabolic health. Conducted in mice, the research points to new possibilities for using brown fat to address metabolic conditions such as insulin resistance and obesity.

The findings were published Sept. 17 in Nature.

Brown fat is unique because it turns energy (calories) from food into heat. Unlike white fat, which stores energy, or muscle, which uses it immediately, brown fat helps keep the body warm in cold environments...

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Physical exercise can ‘train’ the immune system

In addition to strengthening the muscles, lungs, and heart, regular physical exercise also strengthens the immune system. This finding comes from a study of older adults with a history of endurance training, which involves prolonged physical activity such as long-distance running, cycling, swimming, rowing, and walking.

An international team of researchers analyzed the defense cells of these individuals and found that “natural killer” cells, which patrol the body against viruses and diseased cells, were more adaptable, less inflammatory, and metabolically more efficient.

The research, published in the journal Scientific Reports, investigated natural killer (NK) cells...

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Bacterial enzyme and nanoparticle discoveries hold promise for treating gut pain

Fluorescent nanoparticles (purple) carrying a drug to treat pain accumulate in the cells of a mouse colon. Credit: Bunnett Lab

Abdominal pain is a hallmark of many digestive disorders, including inflammatory bowel disease and irritable bowel syndrome. In an effort to develop targeted treatments for gut pain, scientists have discovered a new enzyme in gut bacteria and are using nanoparticles to deliver drugs inside cells.

Currently, there are no treatments specifically for gut pain, and existing painkillers are often insufficient at managing symptoms. These drugs—including opioids, NSAIDs, and steroids—also come with side effects, some of which directly harm the digestive system.

In two new studies published in Cell Host & Microbe and Proceedings of the National Academy of Sci...

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Scientists reverse Alzheimer’s in mice using nanoparticles

Left-hand image:  Light sheet fluorescence microscope images of mouse brain 12h after NOT being treated with nanoparticles. The brains were analyzed to see the amount of Aβ plaques accumulation. Red: Aβ plaques. Green: vessels from the blood brain barrier. Right-hand image: Light sheet fluorescence microscope image of mouse brain 12h after being treated with nanoparticles. The brains were analyzed to see the amount of Aβ plaques accumulation. Red: Aβ plaques. Green: vessels from the blood brain barrier.

A research team co-led by the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital Sichuan University (WCHSU), working with partners in the UK, has demonstrated a nanotechnology strategy that reverses Alzheimer’s disease in mice.

Unlike traditional nanomedici...

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