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Long COVID Puzzle Pieces are Falling into Place—the Picture is Unsettling

Since 2020, the condition known as long COVID-19 has become a widespread disability affecting the health and quality of life of millions of people across the globe and costing economies billions of dollars in reduced productivity of employees and an overall drop in the work force.

The intense scientific effort that long COVID sparked has resulted in more than 24,000 scientific publications, making it the most researched health condition in any four years of recorded human history.

Long COVID is a term that describes the constellation of long-term health effects caused by infection with the SARS-CoV-2 virus...

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Researchers Decipher Mechanisms of Liver Regeneration

Researchers of the BIH decipher mechanisms of liver regeneration
Liver hepatocytes. Credit: Ed Uthman

Scientists from the Berlin Institute of Health at Charité (BIH) and Open Targets together with colleagues from the University of Cambridge, and Addenbrooke’s Hospital in Cambridge, U.K., uncovered mechanisms driving regeneration of the liver during chronic liver disease. This regenerative process allows the liver to repair itself when chronically injured but could also result in progression toward cancer.

The researchers were able to demonstrate this first by performing single-cell analyses on many biopsies obtained from patients with progressive metabolic dysfunction-associated steatotic liver disease (MASLD).

The results obtained in vivo were validated using cultured organoids in the laboratory...

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Using Wobbling Stellar Material, astronomers measure the Spin of a Supermassive Black Hole for the first time

This schematic figure depicts the precession of an accretion disk formed from the debris of a disrupted star around a supermassive black hole (SMBH).

Astronomers at MIT, NASA, and elsewhere have a new way to measure how fast a black hole spins, by using the wobbly aftermath from its stellar feasting.

The method takes advantage of a black hole tidal disruption event—a blazingly bright moment when a black hole exerts tides on a passing star and rips it to shreds. As the star is disrupted by the black hole’s immense tidal forces, half of the star is blown away, while the other half is flung around the black hole, generating an intensely hot accretion disk of rotating stellar material.

The MIT-led team has shown that the wobble of the newly created accretion disk is key to working ...

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Tryptophan in Diet and Gut Bacteria Protect against E. Coli Infection, study shows

Tryptophan in diet, gut bacteria protect against E. coli infection
Dietary Trp protects against infection with C. rodentium strain DBS100 in a mouse model of EHEC infection. Credit: Nature (2024). DOI: 10.1038/s41586-024-07179-5

Gut bacteria and a diet rich in the amino acid tryptophan can play a protective role against pathogenic E. coli, which can cause severe stomach upset, cramps, fever, intestinal bleeding and renal failure, according to a study published March 13 in Nature.

The research reveals how dietary tryptophan—an amino acid found mostly in animal products, nuts, seeds, whole grains and legumes—can be broken down by gut bacteria into small molecules called metabolites...

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