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Scientists can Reverse Brain Aging in Fruit Flies by Preventing Buildup of a Common Protein

Maxim Berg/Unsplash

Humans aren’t the only ones who grow forgetful as they age — fruit flies do, too. But because fruit flies have a lifespan of only about two months, they can be a useful model for understanding the cognitive decline that comes with aging.

A new study published in Nature Communications shows that when a common cell structural protein called filamentous actin, or F-actin, builds up in the brain, it inhibits a key process that removes unnecessary or dysfunctional components within cells, including DNA, lipids, proteins and organelles. The resulting accumulation of waste diminishes neuronal functions and contributes to cognitive decline...

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Scientists Demonstrate Precise Control over Artificial Microswimmers using Electric Fields

Scientists demonstrate control over artificial swimmers using electric fields

In a new study in Physical Review Letters, scientists have demonstrated a method to control artificial microswimmers using electric fields and fluid flow. These microscopic droplets could pave the way for targeted drug delivery and microrobotics.

In the natural world, biological swimmers, like algae and bacteria, can change their direction of movement (or swimming) in response to an external stimulus, like light or electricity. The ability of biological swimmers to change directions in response to electrical fields is known as electrotaxis.

Artificial swimmers that can respond to external stimuli can be extremely helpful for targeted drug delivery applications. In this study, researchers chose to model artificial swimmers that respond to electric fields.

Phys...

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How Vitamin D Deficiency can Lead to Autoimmune Diseases

How vitamin D deficiency can lead to autoimmune diseases
Reduced thymic cellularity and altered T cell development in CypKO mice. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adm9582

As Canadians brace for “vitamin D winter”—months when the sun’s angle is too low to produce the vitamin in the skin—a McGill University study explains why vitamin D deficiency early in life is associated with a higher risk of autoimmune diseases.

During childhood, the thymus helps train immune cells to distinguish between the body’s own tissues and harmful invaders. A vitamin D deficiency at that stage of life causes the thymus to age more quickly, the researchers discovered.

The study is published in the journal Science Advances.

“An aging thymus leads to a ‘leaky’ immune system,” said lead author John White, a Professor in and Chair of M...

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Central Nervous System-associated Macrophages could Modulate Post-Stroke Immune Responses

A CNS-associated macrophage (CAM, in red) at the interface between a blood vessel and an astrocyte (cyan) in a mouse brain. Credit: Levard et al.

An ischemic stroke is a type of stroke that occurs when a blood clot in an artery, also known as thrombus, or the progressive narrowing of arteries, blocks the blood and oxygen flowing to the brain. This process can cause both temporary and permanent brain damage, for instance, leading to partial paralysis, cognitive impairments and other debilitating impairments.

Statistics suggest that older age increases the risk of experiencing ischemic strokes...

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