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Researchers at the University of Colorado Anschutz Medical Campus have found that inhibiting a key protein can stop the destruction of synapses and dendritic spines commonly seen in Alzheimer’s disease.

The study, whose first author is Tyler Martinez, a student in the Pharmacology and Molecular Medicine PhD program at the University of Colorado School of Medicine, was published recently in the journal eNeuro.

The researchers, using rodent neurons, found that targeting a protein called Mdm2 with an experimental cancer drug known as nutlin, stopped neurotoxic amyloid-b peptides that accumulate in Alzheimer’s disease (AD) from overly pruning synapses.

“Cognitive impairments associated with AD correlate with dendritic spine and excitatory synapse loss, particularly within the hip...

New phased-array transmitter design overcomes common problems of CMOS technology in the 300 GHz band, as reported by scientists from Tokyo Tech. Thanks to its remarkable area efficiency, low power consumption, and high data rate, the proposed transmitter could pave the way to many technological applications in the 300 GHz band, including body and cell monitoring, radar, 6G wireless communications, and terahertz sensors.

Today, most frequencies above the 250 GHz mark remain unallocated.

Accordingly, many researchers are developing 300 GHz transmitters/receivers to capital...

In creating five new isotopes, an international research team working at the Facility for Rare Isotope Beams, or FRIB, at Michigan State University has brought the stars closer to Earth.

The isotopes — known as thulium-182, thulium-183, ytterbium-186, ytterbium-187 and lutetium-190 — were reported Feb.

15 in the journal Physical Review Letters.

These represent the first batch of new isotopes made at FRIB, a user facility for the U.S...

Cleveland Clinic researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol.

The team, led by Stanley Hazen, M.D., Ph.D., discovered a link between 4PY, a breakdown product from excess niacin, and heart disease. Higher circulating levels of 4PY were strongly associated with development of heart attack, stroke and other adverse cardiac events in large-scale clinical studies. The researchers also showed in preclinical studies that 4PY directly triggers vascular inflammation which damages blood vessels and can lead to atherosclerosis over time.

The study, published in Nature Medicine, also details genetic links between 4PY and vascular inflammation...