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Benefits of Time-Restricted Eating depend on Age and Sex

Time-Restricted Eating Has Important Health Benefits – Even With Infectious  Diseases Such As COVID-19

Not everyone benefits equally from TRE, but TRE has important health benefits for all. Time-restricted eating (TRE), a dietary regimen that restricts eating to specific hours, has garnered increased attention in weight-loss circles. A new study by Salk scientists further shows that TRE confers multiple health benefits besides weight loss. The study also shows that these benefits may depend on sex and age.

Most TRE studies focus on weight loss in young male mice, but Salk scientists wanted to determine whether TRE confers additional benefits on other populations...

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Engineers grow 3D bioprinted blood vessel

collage of four images demonstrating the process used in the lab
These images depict the method used to fabricate the 3D bioprinted vascular model with native endothelial and vascular smooth muscle cells.

Courtesy of Akhilesh Gaharwar

Vascular diseases such as aneurysms, peripheral artery disease and clots inside blood vessels account for 31% of global deaths. Despite this clinical burden, cardiovascular drug advancements have slowed over the past 20 years. The decrease in cardiovascular therapeutic development is attributed to the lack of efficiency in converting possible treatments into approved methods, specifically due to the discrepancy between studies that take place outside the body compared to inside.

Researchers at Texas A&M University aim to remodel current methodologies to minimize this gap and improve the translatability of these techn...

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Cracking a Mystery of Massive Black Holes and Quasars with Supercomputer Simulations

Distribution of gas across scales, with the gas density increasing from purple to yellow. The top left panel shows a large region containing tens of galaxies (6 million light-years across). Subsequent panels zoom in progressively into the nuclear region of the most massive galaxy and down to the vicinity of the central supermassive black hole. Gas clumps and filaments fall from the inner edge of the central cavity occasionally feeding the black hole. Credit: Anglés-Alcázar et al. 2021, ApJ, 917, 53.
Distribution of gas across scales, with the gas density increasing from purple to yellow. The top left panel shows a large region containing tens of galaxies (6 million light-years across). Subsequent panels zoom in progressively into the nuclear region of the most massive galaxy and down to the vicinity of the central supermassive black hole. Gas clumps and filaments fall from the inner edge of the central cavity occasionally feeding the black hole.
(Credit: Anglés-Alcázar et al. 2021, ApJ, 917, 53.)

Cracking a mystery of massive black holes and quasars with supercomputer simulations. At the center of galaxies, like our own Milky Way, lie massive black holes surrounded by spinning gas...

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Brain Cholesterol Regulates Alzheimer’s Plaques, study reveals

Brain cholesterol regulates Alzheimer's plaques, study reveals
Depletion of cholesterol in astrocytes (right) directly removes amyloid plaques and phosphorylated Tau (left, orange clusters) in an Alzheimer’s mouse model. Credit: Scott Hansen Lab, Scripps Research, Jupiter, Florida.

Advanced imaging technique shows how cholesterol regulates production of Alzheimer’s-associated amyloid beta protein in a type of brain cell.

A team co-led by scientists at Scripps Research has used advanced imaging methods to reveal how the production of the Alzheimer’s-associated protein amyloid beta (Aβ) in the brain is tightly regulated by cholesterol.

Appearing on line Thursday ahead of print in the Aug...

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