Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to
Promote Colorectal Tumorigenesis
The microbiota in the intestines fuels tumor growth. Scientists have made an unexpected discovery while investigating the triggering factors of colon cancer: Cell stress in combination with an altered microbiota in the colon drives tumor growth. Previously, it was assumed that this combination only contributes to inflammatory intestinal diseases.
“With our study we originally wanted to study the role of bacteria in the intestines in the development of intestinal inflammation,” explains Professor Dirk Haller from the Department of Nutrition and Immunology at the Weihenstephan Science Centre of the TUM. “However, the surprising result for us was the discovery that bacteria together with stress in cells caused tumours (exclusively in the colon) and without the involvement of inflammation.”
The investigations were initially carried out using the mouse model. In germ-free (i.e. sterile) animals, in which the activated transcription factor ATF6 regulated stress in the intestinal mucosa (intestinal epithelium), no change could be observed. But as soon as the microbiota, i.e. all the microorganisms in the intestine, were transplanted back into germ-free animals, tumours developed in the colon of the mice. Using Koch’s postulates, Haller and his team were able to show that microorganisms are involved in the development of cancer in the colon.
The transcription factor ATF6 regulates stress in cells, and the intensity and duration of activation is increased with diseases. “However, it is not cell stress alone that leads to tumour growth, but the combination of stress and microbiota that favours cancer growth,” says Haller, head of ZIEL – the Institute for Food & Health at TUM.
ATF6 incidence found to be increased in colon cancer patients. Subsequently, in cooperation with the clinic on the right side of the Isar (Prof. Janssen), the data of 541 patients with colon cancer were examined. In those cases where the level of transcription factor ATF6, which triggers cell stress, was significantly increased, the recurrence rate after surgery increased: About 10% of patients were at risk of getting colon cancer a second time.
“In certain patients, the protein ATF6 could serve as a diagnostic marker for an increased risk of colon cancer and could indicate the start of therapy at an early stage,” said Prof. Haller – “a microbial therapy is conceivable, when we know more about the composition of the bacterial flora. What now became clear, however: Chronic inflammation has no effect on cancer development in the colon.” https://www.tum.de/nc/en/about-tum/news/press-releases/detail/article/34947/
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