Neutrophils mediate delivery of nanoparticles (NPs) across blood vessel barrier into the tumor tissues after acute inflammation induced by photosensitization (PS).
Technique targets disease, spares nearby tissues. For the first time, WSU researchers have demonstrated a way to deliver a drug to a tumor by attaching it to a white blood cell. The innovation could let doctors target tumors with anticancer drugs that might otherwise damage healthy tissues. A team led by Zhenjia Wang, an assistant professor of pharmaceutical sciences attached a nanoscale particle to a WBC. The showed they could get a drug past the armor of blood vessels that typically shield a tumor. This has been a major challenge in nanotechnology drug delivery.
Wang implanted a tumor on the flank of a mouse commonly chosen as a model for human diseases. The tumor was exposed to near-infrared light, causing an inflammation that released proteins to attract neutrophils, into the tumor. The researchers then injected the mouse with gold nanoparticles treated with antibodies that mediate the union of the nanoparticles and neutrophils. When the tumor was exposed to infrared light, the light’s interaction with the gold nanoparticles produced heat that killed the cancer cells, Wang said.
In the future, therapists could attach an anticancer drug like doxorubicin to the nanoparticle. This could let them deliver the drug directly to the tumor and avoid damaging nearby tissues, Wang said. “We have developed a new approach to deliver therapeutics into tumors using the white blood cells of our body,” Wang said. “This will be applied to deliver many anticancer drugs, such as doxorubicin, and we hope that it could increase the efficacy of cancer therapies compared to other delivery systems.” http://onlinelibrary.wiley.com/doi/10.1002/adma.201701021/abstract https://news.wsu.edu/2017/05/15/nanotherapeutics-target-tumor-at-wsu/
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