Dynamic cerebral reorganization in the pathophysiology of schizophrenia: a, MRI-derived cortical thickness study. Credit: Lena Palaniyappan
A team of scientists from across the globe have shown that the brains of patients with schizophrenia have the capacity to reorganize and fight the illness. This is the first time that imaging data has been used to show that our brains may have the ability to reverse the effects of schizophrenia. Schizophrenia is an illness generally associated with a widespread reduction in brain tissue volume. However, a recent study found that a subtle increase in tissue also occurs in certain brain regions.
The study followed 98 patients with schizophrenia vs 83 patients without schizophrenia. The team used MRI and a sophisticated covariance analysis to record the amount of brain tissue increase. Due to the subtlety and the distributed nature of increase, this had not been demonstrated in patients before now.
The team’s next step is to clarify the evolution of this brain tissue reorganization process by repeatedly scanning individual patients with early schizophrenia and study the effect of this reorganization on their recovery.
“These findings are important not only because of their novelty and the rigour of the study, but because they point the way to the development of targeted treatments that potentially could better address some of the core pathology in schizophrenia,” explains Dr. Jeffrey Reiss, Site Chief, Psychiatry, LHSC. “Brain plasticity and the development of related therapies would contribute to a new optimism in an illness that was 100 years ago described as premature dementia for its seemingly progressive deterioration.”
“Dr. Palaniyappan and his colleagues have opened new avenues of research into our understanding of schizophrenia,” says Dr. Paul Links, Chair/Chief, Psychiatry, LHSC. “Their findings may lead us to be able to harness the brain’s own compensatory changes in the face of this illness and improve recovery. We are excited that Dr. Palaniyappan will be continuing this important clinical research here in London with his international colleagues.”
https://www.lawsonresearch.ca/news/imaging-study-shows-promising-results-patients-schizophrenia
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