Highlights
•OA inhibits the binding of proteins containing RRM.
•OA rescues processing of pri-miR-7 in vitro.
•OA induces mature miR-7 production in HeLa cells.
A compound found in olive oil may help to prevent cancer developing in the brain, a study shows. Research into oleic acid – the primary ingredient in olive oil – has shown how it can help prevent cancer-causing genes from functioning in cells. The oily substance – a fatty acids – stimulates the production of a cell molecule whose function is to prevent cancer-causing proteins from forming.
The study team says it is too soon to say whether dietary consumption of olive oil may help prevent brain cancer. Their findings, however, point towards possible therapies based on the oil to prevent brain cancer from occurring. Scientists from the University of Edinburgh analysed the effect of oleic acid on a cell molecule, known as miR-7, which is active in the brain and is known to suppress the formation of tumours.
They found that oleic acid prevents a cell protein, MSI2, from stopping production of miR-7. In this way, the olive oil component supports the production of miR-7, which helps prevent tumours from forming. Researchers made their discoveries in tests on human cell extracts and in living cells.
Dr Gracjan Michlewski of the University of Edinburgh’s School of Biological Sciences said: “While we cannot yet say that olive oil in the diet helps prevent brain cancer, our findings do suggest that oleic acid can support the production of tumour-suppressing molecules in cells grown in the lab. Further studies could help determine the role that olive oil might have in brain health.”
http://www.sciencedirect.com/science/article/pii/S0022283617301997 http://www.ed.ac.uk/news/2017/olive-oil-nutrient-may-help-prevent-brain-cancer
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