Why do some people age faster than others? Study identifies genes at play

Why do some people age faster than others? Study IDs genes at play

It’s a fact of life: Some people age better than others. Some ease into their 90s with mind and body intact, while others battle diabetes, Alzheimer’s or mobility issues decades earlier. Some can withstand a bad fall or bout of the flu with ease, while others never leave the hospital again.

New University of Colorado Boulder-led research, published in Nature Genetics, sheds light on why that is.

In it, an international team of co-authors identifies more than 400 genes associated with accelerated aging across seven different sub-types. The study reveals that different groups of genes underlie different kinds of disordered aging, a.k.a. frailty, ranging from cognitive decline to mobility issues to social isolation.

The findings lend support to what is known as the “geroscience ...

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Advanced battery electrode processing technologies show promise for cutting energy use in half

Taking battery manufacturing to the next level
As part of the conventional wet electrode processing approach, a slurry is cast onto a substrate. Credit: Nature Reviews Clean Technology (2025). DOI: 10.1038/s44359-024-00018-w

Numerous market analyses have shown that over the next five years, demand for lithium-ion batteries for everything from personal electric devices to grid-scale energy storage is expected to grow dramatically.

To meet this demand, battery manufacturing needs to be faster, cheaper, more dependable, less energy-intensive and less wasteful. A key part of lithium-ion battery manufacturing with significant room for improvement is the processing and fabrication of electrodes.

To facilitate advances in this area, researchers at the U.S...

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X-ray and Radio go ‘Hand in Hand’ in New Image

X-ray: NASA/CXC/Univ. of Hong Kong/S. Zhang et al.; Radio: ATNF/CSIRO/ATCA; H-alpha: UK STFC/Royal Observatory Edinburgh; Image Processing: NASA/CXC/SAO/N. Wolk

In 2009, NASA’s Chandra X-ray Observatory released a captivating image: a pulsar and its surrounding nebula that is shaped like a hand. Since then, astronomers have used Chandra and other telescopes to continue to observe this object. Now, new radio data from the Australia Telescope Compact Array (ATCA) has been combined with Chandra’s X-ray data to provide a fresh view of this exploded star and its environment, to help understand its peculiar properties and shape.

At the center of this new image lies the pulsar B1509-58, a rapidly spinning neutron star that is only about 12 miles in diameter...

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RNA editing tool can take some of the risk out of gene therapy

Risk management: Making gene therapy safer and more effective
Graphical abstract. Credit: Cell (2025). DOI: 10.1016/j.cell.2025.07.032

The ability to correct disease-causing genetic mistakes using genome editors holds great promise in medicine, but it is not without risk. When this type of “genetic surgery” is performed on DNA, for instance, there is always the danger of leaving permanent genetic scars that may even be heritable.

To alleviate this risk, researchers have experimented with gene editing processes on messenger RNA (mRNA), a central link between DNA and proteins that doesn’t carry the same risks because it doesn’t involve permanent changes to the DNA. But existing RNA editing tools have proven either too cumbersome to use or too toxic to human cells.

Yale researchers have developed a new—and safe—family of RNA-editing tools th...

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