Newly discovered compounds help cells fight a wide range of viruses

A virus being destroyed by beams of light
Researchers at MIT and other institutions have discovered broad-spectrum antiviral compounds through the use of a novel optogenetic screen, symbolized in this image by a beam of light piercing a virus.
Credits:Credit: Kendall Pata, Type A Creative; edited by MIT News

Researchers at MIT and other institutions have identified compounds that can fight off viral infection by activating a defense pathway inside host cells. These compounds, they believe, could be used as antiviral drugs that work against not just one but any kind of virus.

The researchers identified these compounds, which activate a host cell defense system known as the integrated stress response pathway, in a screen of nearly 400,000 molecules...

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Scientists successfully develop half metal material that conducts single-spin electrons

The world's first 2D half metal created at Forschungszentrum Jülich
Two atoms thick layer of iron and palladium (left, yellow/red): Experiments with spin-resolved momentum microscopy show that only electrons with a specific spin direction (indicated as red/blue) can be found on the so-called Fermi surface and thus actively contribute to charge transport. Credit: Forschungszentrum Jülich / Xin Liang Tan

Researchers at Forschungszentrum Jülich have successfully created the world’s first experimentally verified two-dimensional half metal—a material that conducts electricity using electrons of just one spin type: either “spin-up” or “spin-down.” Their findings, now published as an Editors’ Suggestion in Physical Review Letters, mark a milestone in the quest for materials enabling energy-efficient spintronic that go beyond conventional electronics.

H...

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What has Webb taught us about rocky exoplanets so far?

What has Webb taught us about rocky exoplanets so far?
Artist’s impression of the surface of Barnard’s Star b. Credit: ESO/M. Kornmesser

The hunt for potentially habitable rocky planets in our galaxy has been the holy grail of exoplanet studies for decades. While the discovery of more than 5,900 exoplanets in more than 4,400 planetary systems has been a remarkable achievement, only a small fraction (217) have been confirmed as terrestrial—aka rocky or “Earth-like.” Furthermore, obtaining accurate information on a rocky exoplanet’s atmosphere is very difficult, since potentially habitable rocky planets are much smaller and tend to orbit closer to their stars.

Thanks to next-generation instruments like the James Webb Space Telescope (JWST), exoplanet studies are transitioning from discovery to characterization...

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AI tool spots hidden heart disease using routine electrocardiogram data

With the help of artificial intelligence (AI), an inexpensive test found in many doctors’ offices may soon be used to screen for hidden heart disease.

Structural heart disease, including valve disease, congenital heart disease, and other issues that impair heart function, affects millions of people worldwide. Yet in the absence of a routine, affordable screening test, many structural heart problems go undetected until significant function has been lost.

“We have colonoscopies, we have mammograms, but we have no equivalents for most forms of heart disease,” says Pierre Elias, assistant professor of medicine and biomedical informatics at Columbia University Vagelos College of Physicians and Surgeons and medical director for artificial intelligence at NewYork-Presbyterian.

Elias...

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