What Standing on One Leg can tell you: Biological Age

How long a person can stand — on one leg — is a more telltale measure of aging than changes in strength or gait, according to new Mayo Clinic research. The study appears today in the journal PLOS ONE.

Good balance, muscle strength and an efficient gait contribute to people’s independence and well-being as they age. How these factors change, and at what rate, can help clinicians develop programs to ensure healthy aging. Individually, people can train their balance without special equipment and work on maintaining it over time.

In this study, 40 healthy, independent people over 50 underwent walking, balance, grip strength and knee strength tests. Half of the participants were under 65; the other half were 65 and older.

In the balance tests, participants stood on force plates in...

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A “Chemical ChatGPT” for New Medications

Three-dimensional structures of two target proteins,
Three-dimensional structures of two target proteins, – histone deacetylase 6 (blue) and tyrosine-protein kinase JAK2 (red), together with a selective inhibitor of each enzyme. The dual inhibitor in the center is active against both targets. The prediction of compounds with predefined dual-target activity is the task of the chemical language model.© Figure: Sanjana Srinivasan & Jürgen Bajorath

Researchers from the University of Bonn have trained an AI process to predict potential active ingredients with special properties. Therefore, they derived a chemical language model — a kind of ChatGPT for molecules. Following a training phase, the AI was able to exactly reproduce the chemical structures of compounds with known dual-target activity that may be particularly effective medications...

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Physicists Discover First ‘Black Hole Triple’

Illustration of a black hole at the center of a galaxy in the process of consuming a nearby star, which looks like an orange blob. A second, more regular, star appears at a distance.

System observed 8,000 light-years away may be the first direct evidence of ‘gentle’ black hole formation. A surprising discovery about the black hole V404 Cygnus is expanding our understanding of black holes, the objects they can host, and the way they form.

Many black holes detected to date appear to be part of a pair. These binary systems comprise a black hole and a secondary object — such as a star, a much denser neutron star, or another black hole — that spiral around each other, drawn together by the black hole’s gravity to form a tight orbital pair.

Now a surprising discovery is expanding the picture of black holes, the objects they can host, and the way they form.

In a study appearing in Nature, physicists at MIT and Caltech report that they have observed a “black hole...

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How Vitamin D Deficiency can Lead to Autoimmune Diseases

How vitamin D deficiency can lead to autoimmune diseases
Reduced thymic cellularity and altered T cell development in CypKO mice. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adm9582

As Canadians brace for “vitamin D winter”—months when the sun’s angle is too low to produce the vitamin in the skin—a McGill University study explains why vitamin D deficiency early in life is associated with a higher risk of autoimmune diseases.

During childhood, the thymus helps train immune cells to distinguish between the body’s own tissues and harmful invaders. A vitamin D deficiency at that stage of life causes the thymus to age more quickly, the researchers discovered.

The study is published in the journal Science Advances.

“An aging thymus leads to a ‘leaky’ immune system,” said lead author John White, a Professor in and Chair of M...

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