Gut-derived metabolite hippuric acid ‘turns up’ immune inflammation, study finds

Scientists discover how gut-derived metabolite acts as immune 'Volume knob' via macrophages
Graphical abstract. Credit: Cell Reports (2026). DOI: 10.1016/j.celrep.2025.116749

Scientists at The Wistar Institute have identified a previously overlooked mediator in the body’s response to life-threatening infections: hippuric acid, a metabolite produced when gut bacteria break down polyphenols from berries, tea, and other plant-based foods. The research reveals that this molecule acts as an immune-system amplifier, boosting the body’s inflammatory defenses during early infection but elevating them to deadly levels when infections progress to sepsis.

Published in Cell Reports, the study demonstrates that elevated hippuric acid levels correlate with increased mortality in sepsis patients, while also uncovering the molecular mechanisms by which this metabolite modifies immune re...

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Record-breaking photons at telecom wavelengths – on-demand

Record-breaking photons at telecom wavelengths — on demand
Nico Hauser (left) with other researchers from the Barz group, University of Stuttgart. Credit: Barz Group, University of Stuttgart / Ludmilla Parsyak

A team of researchers from the University of Stuttgart and the Julius-Maximilians-Universität Würzburg led by Prof. Stefanie Barz (University of Stuttgart) has demonstrated a source of single photons that combines on-demand operation with record-high photon quality in the telecommunications C-band—a key step toward scalable photonic quantum computation and quantum communication. “The lack of a high-quality on-demand C-band photon source has been a major problem in quantum optics laboratories for over a decade—our new technology now removes this obstacle,” says Prof. Stefanie Barz.

The key: Identical photons on demand
In everyday ...

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New 3D map of the sun’s magnetic interior could improve predictions of disruptive solar flares

New 3D map of the sun's magnetic interior could improve predictions of disruptive solar flares
Panels (a), (b), and (c) show the 3D evolution of the toroidal field during Cycle 23 at three different times. (d) Time–latitude plot of the azimuthally averaged toroidal field that shows the equatorward migration. (e) Here, we show the contribution of the nonaxisymmetric toroidal field at different depths of the convection zone. Credit: The Astrophysical Journal Letters (2026). DOI: 10.3847/2041-8213/ae3138

For the first time, scientists have used satellite data to create a 3D map of the sun’s interior magnetic field, the fundamental driver of solar activity. The research, published in The Astrophysical Journal Letters, should enable more accurate predictions of solar cycles and space weather that affects satellites and power grids.

Magnetic star
The sun is more than just a fier...

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First observation of ultra-thin 2D materials in a state between solid and liquid

Strange In-Between State of Matter Observed
The Protochips Fusion heating stage and chip used in the Nion electrical module, which enabled the scientists to conduct controlled high-temperature studies in the vacuum of the microscope. Credit: Jani Kotakoski

When a crystal is just one atom thick, melting gets weird — and scientists have finally caught it on camera.
When materials become just one atom thick, melting no longer follows the familiar rules. Instead of jumping straight from solid to liquid, an unusual in-between state emerges, where atomic positions loosen like a liquid but still keep some solid-like order. Scientists at the University of Vienna have now captured this elusive “hexatic” phase in real time by filming an ultra-thin silver iodide crystal as it melted inside a protective graphene sandwich.

When ice t...

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