An estimated one in five Americans live with chronic pain and current treatment options leave much to be desired. Feixiong Cheng, Ph.D., Director of Cleveland Clinic’s Genome Center, and IBM are using artificial intelligence (AI) for drug discovery in advanced pain management. The team’s deep-learning framework identified multiple gut microbiome-derived metabolites and FDA-approved drugs that can be repurposed to select non-addictive, non-opioid options to treat chronic pain.

The findings, published in Cell Press, represent one of many ways the organizations’ Discovery Accelerator partnership is helping to advance research in healthcare and life sciences.

Treating chronic pain with opioids is still a challenge due to the risk of severe side eff...

NASA plans to send crewed missions to Mars over the next decade—but the 140 million-mile (225 million-kilometer) journey to the red planet could take several months to years round trip.

This relatively long transit time is a result of the use of traditional chemical rocket fuel. An alternative technology to the chemically propelled rockets the agency develops now is called nuclear thermal propulsion, which uses nuclear fission and could one day power a rocket that makes the trip in just half the time.

Nuclear fission involves harvesting the incredible amount of energy released when an atom is split by a neutron. This reaction is known as a fission reaction...

A research team from the University of California, Irvine is the first to reveal that a molecule in the brain—ophthalmic acid—unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, offering a new therapeutic target for Parkinson’s and other movement diseases.

In the study, published in the October issue of the journal Brain, researchers observed that ophthalmic acid binds to and activates calcium-sensing receptors in the brain, reversing the movement impairments of Parkinson’s mouse models for more than 20 hours.

The disabling neurogenerative disease affects millions of people worldwide over the age of 50...

Plastic pollution is everywhere, and a good amount of it is composed of polyethylene terephthalate (PET). This polymer is used to make bottles, containers and even clothing. Now, researchers report in Environmental Science & Technology that they have discovered an enzyme that breaks apart PET in a rather unusual place: microbes living in sewage sludge. The enzyme could be used by wastewater treatment plants to break apart microplastic particles and upcycle plastic waste.

Microplastics are becoming increasingly prevalent in places ranging from remote oceans to inside bodies, so it shouldn’t be a surprise that they appear in wastewater as well.

However, the particles are so tiny th...