Researchers Discover New Bacterium that Causes Gut Immunodeficiency

Thaddeus Stappenbeck, M.D., Ph.D., (left) and Qiuhe Lu, Ph.D., in the lab.
Thaddeus Stappenbeck, M.D., Ph.D., (left) and Qiuhe Lu, Ph.D., in the lab.

Cleveland Clinic researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases.

The team identified the bacterium, Tomasiella immunophila (T. immunophila), which plays a key role in breaking down a crucial immune component of the gut’s multi-faceted protective immune barrier.

Identifying this bacterium is the first step to developing new treatments for a variety of inflammatory and infectious gut diseases...

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As LLMs Grow Bigger, they’re more likely to give Wrong Answers than Admit Ignorance

As LLMs grow bigger, they're more likely to give wrong answers than admit ignorance
Performance of a selection of GPT and LLaMA models with increasing difficulty. Credit: Nature (2024). DOI: 10.1038/s41586-024-07930-y

A team of AI researchers at Universitat Politècnica de València, in Spain, has found that as popular LLMs (Large Language Models) grow larger and more sophisticated, they become less likely to admit to a user that they do not know an answer.

In their study published in the journal Nature, the group tested the latest version of three of the most popular AI chatbots regarding their responses, accuracy, and how good users are at spotting wrong answers.

As LLMs have become mainstream, users have become accustomed to using them for writing papers, poems or songs and solving math problems and other tasks, and the issue of accuracy has become a bigger...

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Circadian Disruption, Gut Microbiome Changes linked to Colorectal Cancer Progression

Circadian disruption, gut microbiome changes linked to colorectal cancer progression
Clock disruption and cancer alter microbial structure. Credit: Science Advances (2024). DOI: 10.1126/sciadv.ado1458

Research from the University of California, Irvine has revealed how disruption of the circadian clock, the body’s internal, 24-hour biological pacemaker, may accelerate the progression of colorectal cancer by affecting the gut microbiome and intestinal barrier function. This discovery offers new avenues for prevention and treatment strategies.

The study, published online today in the journal Science Advances, offers a more comprehensive understanding of how important changes occur in the function and composition of the gut microbiome when the circadian clock is disturbed in the presence of colorectal cancer.

“There is an alarming rise in early-onset colorectal can...

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ESO Telescope Captures the Most Detailed Infrared Map ever of our Milky Way

Astronomers have published a gigantic infrared map of the Milky Way containing more than 1.5 billion objects — the most detailed one ever made. Using the European Southern Observatory’s VISTA telescope, the team monitored the central regions of our Galaxy over more than 13 years. At 500 terabytes of data, this is the largest observational project ever carried out with an ESO telescope.

“We made so many discoveries, we have changed the view of our Galaxy forever,” says Dante Minniti, an astrophysicist at Universidad Andrés Bello in Chile who led the overall project.

This record-breaking map comprises 200,000 images taken by ESO’s VISTA — the Visible and Infrared Survey Telescope for Astronomy...

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