PROPYLENE GLYCOL
~ also known as 1,2-propanediol; 1,2-dihydroxypropane, Propane-1,2-diol; 57-55-6; 1,2-Propylene glycol; etc. is a is a synthetic organic compound. The global propylene glycol market is projected to reach USD 4.60 billion by 2021, at a CAGR of 5.8% from 2016 to 2021
Chemical structure: C3H8O2 (CH3CHOHCH2OH). is sometimes called α-propylene glycol to distinguish it from the isomer propane-1,3-diol (β-propylene glycol).
Properties: Propylene glycol is a clear, colorless and hygroscopic liquid. Propylene glycol contains an asymmetrical carbon atom, so
two enantiomers. The commercial product is a racemic mixture. Pure optical isomers can be obtained by hydration of optically pure propylene oxide.It is non-corrosive and has very low volatility and toxicity. Chemically it is classed as a diol and is miscible with a broad range of solvents, including water, acetone, and chloroform.
Production:
Propylene glycol is produced industrially or in the laboratory.
- Industrially, propylene glycol is produced from propylene oxide (for food-grade use). Different manufacturers use either non-catalytic high-temperature process at 200 °C (392 °F) to 220 °C (428 °F), or a catalytic method, which proceeds at 150 °C (302 °F) to 180 °C (356 °F) in the presence of ion exchange resin or a small amount of sulfuric acid or alkali.
- In the laboratory, S-Propanediol may be synthesized from D-mannitol, through the following scheme:
Chemical reactions and Uses:
Propylene glycol reacts with a mixture of unsaturated maleic anhydride and isophthalic acid to give a copolymer. This partially unsaturated polymer undergoes further crosslinking to yield thermoset plastics. Related to this usage, propylene glycol reacts with propylene oxide to give oligomers and polymers that are used to produce polyurethanes.
Propylene glycol is used as a humectant (E1520), solvent, and preservative in food and for tobacco products. It is also one of the major ingredients of the e-liquid and cartridges used in electronic cigarettes where it is aerosolized in the atomizer. Propylene glycol is also used in various edible items such as coffee-based drinks, liquid sweeteners, ice cream, whipped dairy products and soda. Vaporizers used for delivery of pharmaceuticals or personal-care products often include propylene glycol among the ingredients. Propylene glycol is used as a solvent in many pharmaceuticals, including oral, injectable and topical formulations, such as for diazepam and lorazepam which are insoluble in water. Certain formulations of artificial tears, such as Systane, use propylene glycol as an ingredient.
In veterinary medicine, propylene glycol is used as an oral treatment for hyperketonaemia in ruminants.
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