Tohoku University and Japan Advanced Institute of Science and Technology research group has developed a molecular robot consisting of biomolecules, eg DNA and protein. Molecular machines were integrated into an artificial cell membrane. It can start and stop its shape-changing function in response to a specific DNA signal. This is the first time that a molecular robotic system has been able to recognize signals and control its shape-changing function. What this means is that molecular robots could, in the near future, function in a way similar to living organisms.
Using biomolecules like DNA and proteins, living organisms perform important functions. Eg white blood cells can chase bacteria by sensing chemical signals and migrating toward the target. In chemistry and synthetic biology, elemental technologies for making various molecular machines, such as sensors, processors and actuators, are created using biomolecules.
The system could lead to a significant breakthrough – a bio-inspired robot designed on a molecular basis. The molecular robot is about 1 millionth of a meter – similar in size to human cells. It consists of a molecular actuator, composed of protein, and a molecular clutch, composed of DNA. The shape of the robot’s body (artificial cell membrane) can be changed by the actuator, while the transmission of the force generated by the actuator can be controlled by the molecular clutch.
Through experiments the molecular robot could start and stop the shape-changing behavior in response to a specific DNA signal. “With more than 20 chemicals at varying concentrations, it took us a year and a half to establish good conditions for working our molecular robots,” says Associate Professor Shin-ichiro Nomura. “It was exciting to see the robot shape-changing motion through the microscope. It meant our designed DNA clutch worked perfectly, despite the complex conditions inside the robot.”
The realization of a molecular robot whose components are designed at a molecular level and who can function in a small and complicated environment, such as the human body, is expected to significantly expand the possibilities of robotics engineering, eg treatment robot for live culturing cells and a monitoring robot for checking environmental pollution.
“The paper by Nomura and coworkers represents a major step towards the development of autonomous soft microrobots,” says Dr. Friedrich Simmel, professor at the Technische Universität München. “Based on this achievement, in the future similar systems could be developed that display artificial phototaxis or chemotaxis, or similar ‘intelligent’ behavior.” http://www.tohoku.ac.jp/en/press/molecular_robot.html
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