Smart Immune Cells teach Neurons damaged by Parkinson’s to Heal themselves
As a potential treatment for Parkinson’s disease, scientists have created smarter immune cells that produce and deliver a healing protein to the brain while also teaching neurons to begin making the protein for themselves.
The researchers, led by A/Prof Elena Batrakova at UNC Eshelman School of Pharmacy’s Center for Nanotechnology in Drug Delivery, genetically modified macrophages to produce glial cell-derived neurotrophic factor, or GDNF, and deliver it to the brain. Glial cells provide support and protection for nerve cells throughout the brain and body, and GDNF can heal and stimulate the growth of damaged neurons.
“Currently, there are no treatments that can halt or reverse the course of Parkinson’s disease. There are only therapies to address quality of life, such as dopamine replacement,” Batrakova said. “However, studies have shown that delivering neurotrophic factor to the brain not only promotes the survival of neurons but also reverses the progression of Parkinson’s disease.” Besides delivering GDNF, the engineered macrophages can “teach” neurons to make the protein for themselves by delivering both the tools and the instructions needed: DNA, mRNA and transcription factor.
Successfully delivering the treatment to the brain is the key to the success of GDNF therapy, said Batrakova. Using immune cells avoids the body’s natural defenses. The repurposed macrophages are also able to penetrate the blood-brain barrier, something most medicines cannot do. The reprogrammed cells travel to the brain and produce exosomes that contain GDNF. The cells release the exosomes, which then are able to deliver the proteins to neurons in the brain.
“By teaching immune system cells to make this protective protein, we harness the natural systems of the body to combat degenerative conditions like Parkinson’s disease,” Batrakova said. https://uncnews.unc.edu/?p=49153&preview=true
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