Schematic representation of the contribution of soluble ADAM33 (sADAM33) as a local tissue susceptibility gene in asthma pathobiology.
A potential novel way of preventing asthma at the origin of the disease has been found, a finding that could challenge the current understanding of the condition. Insight, analysed the impact of the gene ADAM33, which is associated with the development of asthma. ADAM33 makes an enzyme, which is attached to cells in the airway muscles. When the enzyme loses its anchor to the cell surface, it is prone to going rogue around the lung causing poorer lung function in people who have asthma.
The studies in human tissue samples and mice, led by A/Prof Hans Michel Haitchi suggests that if you inhibit ADAM33 or prevent it from going rouge, the features of asthma – airway remodelling (more muscle and blood vessels around the airways), twitchiness and inflammation — will be reduced.”This finding radically alters our understanding of the field, to say the least,” says Professor Haitchi. “For years we have thought that airway remodelling is the result of the inflammation caused by an allergic reaction, but our research tells us otherwise.”
The first study showed that rogue human ADAM33 causes airway remodelling resulting in more muscle and blood vessels around the airways of developing lungs but it did not cause inflammation. When a house dust mite allergen was introduced, which is a common human allergen, both, airway remodelling and allergic airway inflammation were more significantly enhanced. In another study, remodelling of the airway was shown in mice that had ADAM33 switched on from in utero. The gene was then switched off and the airway remodelling was completely reversed.
Furthermore they studied the impact of house dust mite allergen on asthma features in mice that had the ADAM33 gene removed. Airway remodelling and twitchiness as well as airway inflammation rates were significantly reduced by 50% and respectively 35% in mice that did not have the rogue gene. These findings identify ADAM33 as a target for disease modifying therapy in asthma.
ADAM33 initiated airway remodelling reduces the ability of the lungs to function normally, which is not prevented by current anti-inflammatory steroid therapy. Therefore, stopping this ADAM33 induced process would prevent a harmful effect that promotes the development of allergic asthma for many of the 5.4 million people in the UK with the condition.” http://www.southampton.ac.uk/news/2016/07/adam-33-gene.page
https://insight.jci.org/articles/view/87632
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