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    β1-integrin tagged posts

    Scientists found means to Inhibit Capillary Leakage in Sepsis

    July 1, 2018, Categories  Biology/Biotechnology, Health/Medical

    Leakage of the vascular tracer (red) from dermal blood vessels (green) in systemic inflammation. Credit: Laura Hakanpaa / Saharinen Lab.

    Leakage of the vascular tracer (red) from dermal blood vessels (green) in systemic inflammation.
    Credit: Laura Hakanpaa / Saharinen Lab.

    Increased capillary permeability and subsequent leakage from the capillaries is associated with numerous difficult-to-cure diseases, including acute respiratory distress syndrome (ARDS), severe Dengue fever and malaria, and sepsis. Currently, there is no effective therapy to inhibit capillary leakage and to maintain vessel stability in these diseases. The latest research published in the Proceedings of the National Academy of Sciences indicates that a monoclonal antibody targeted against β1-integrin inhibits vascular leakage in a mouse model of sepsis.

    Integrins are heterodimeric cell surface receptors that mediate interactions between cells and the surro...

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    Protein found to Bolster Growth of Damaged Muscle tissue

    July 19, 2016, Categories  Biology/Biotechnology, Health/Medical

    Activating [beta]1-integrin in mdx mice ameliorates dystrophic pathology and restores muscle strength.

    Activating β1-integrin in mdx mice ameliorates dystrophic pathology and restores muscle strength.

    This could potentially contribute to Rx for muscle degeneration caused by old age and diseases such as muscular dystrophy. A particular type of protein called integrin is present on the stem cell surface and used by stem cells to interact with, or “sense” their surroundings. How stem cells sense their surroundings, also known as the stem cell “niche,” affects how they live and last for regeneration. The presence of the protein β1-integrin was shown to help promote the transformation of those undifferentiated stem cells into muscle after the tissue has degraded, and improve regenerated muscle fiber growth as much as 50%.

    The experiment shows that β1-integrin – one of 28 types of integrin – mai...

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