γδ T cells tagged posts

Scientists identify immune molecule that keeps Metabolism in tune and on time

Scientists identify immune molecule that keeps metabolism in tune and on time
Innate IL-17+ T cells are enriched for molecular-clock genes. Credit: Nature (2024). DOI: 10.1038/s41586-024-08131-3

Recent research reveals that the immune system interacts with the body’s internal clock, influencing both fat storage and temperature regulation.

The discovery hints at why shift workers and others with irregular work, eating, or sleep patterns driven by the demands of modern life fall out of metabolic sync, and may hold potential for developing therapies to address obesity and prevent wasting.

The key finding—that an immune molecule within adipose (fat) tissue, known as interleukin-17A (IL-17A), plays a regulatory role in fat storage—holds significant therapeutic potential for addressing obesity, preventing wasting, and mitigating other metabolic disorders...

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