Intestinal cells in a healthy individual in which the non-coding RNA of the Inc13 gene appears in red (the red dots would not be seen in a celiac patient). Credit: Image courtesy of University of the Basque Country
40% of the population carry the main risk factor for celiac disease but only 1% go down with it. A new gene that influences its development has been found in what until recently has been known as ‘junk’ DNA.
It has been known for some time that celiac disease develops in people who have a genetic susceptibility, but despite the fact that 40% of the population carry the most decisive risk factor (the HLA-DQ2 and DQ8 polymorphisms), only 1% go on to develop the disease...
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