Walter and Eliza Hall Institute researchers have generated the first 3-D map of the cancer-associated protein DCLK1, revealing how it functions. Credit: Walter and Eliza Hall Institute, Australia
Walter and Eliza Hall Institute researchers have revealed for the first time the three-dimensional molecular ‘map’ of a protein that has been pinpointed as a driver of many types of cancers. The unprecedented view of the protein doublecortin kinase like domain 1 (DCLK1) could provide clues to how it contributes to cancer formation and progression. DCLK1 assembles scaffolds within microtubules. These rope-like structures give cells shape, enable movement and cell division, and are crucial in enabling the growth and spread of cancer cells...
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