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    3D structure of DNA that brings promoters and enhancers together tagged posts

    Locking down the Big Bang of Immune Cells

    September 24, 2017, Categories  Biology/Biotechnology, Health/Medical

    Schematic diagram showing how a subset of immune cells, named DN2a T cells, mature into DN2b T cells. The maturation of this step is among the earliest in immune cell development and is controlled by the forgotten DNA strands that allow the genome to change its architecture to induce the “Big Bang” of T cell development. In the absence of the “forgotten strands” DN2a cells fail to mature and ultimately after accumulating additional mutations become malignant T cells also named leukemias or lymphomas. Credit: UC San Diego

    Schematic diagram showing how a subset of immune cells, named DN2a T cells, mature into DN2b T cells. The maturation of this step is among the earliest in immune cell development and is controlled by the forgotten DNA strands that allow the genome to change its architecture to induce the “Big Bang” of T cell development. In the absence of the “forgotten strands” DN2a cells fail to mature and ultimately after accumulating additional mutations become malignant T cells also named leukemias or lymphomas.
    Credit: UC San Diego

    Ignored pieces of DNA play a critical role in the development of immune cells (T cells). These areas activate a change in the structure of DNA that brings together crucial elements necessary for T cell formation...

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