AAV-KP1 tagged posts

Gene Therapy Research offers hope for people with Chronic Kidney Disease

Gene therapy research offers hope for people with chronic kidney disease
A mechanistic model of AAV9 and AAV-KP1-mediated renal transduction. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-54475-9

Researchers are making strides in improving gene therapies for genetic diseases, particularly chronic kidney disease, using adeno-associated virus, or AAV, vectors. While AAV-based treatments have shown promise, delivering these therapies effectively to the kidneys has remained a challenge—until now.

There are many different types of AAV capsids—the protein shells of virus particles—that have been used to deliver genes to cells, each with unique effects...

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