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    abnormal lipid metabolism of the brain tagged posts

    Alzheimer’s disease thought to be Accelerated by an Abnormal Build-up of Fatty Acids in the Brain

    August 27, 2015, Categories  Biology/Biotechnology, Health/Medical

    Early NSC impairment in 3xTg-AD mice correlates with SVZ niche lipid accumulations • Similar lipid accumulations are found in the SVZ in postmortem human AD brains • Accumulating SVZ lipids are locally generated, oleic acid-enriched triglycerides • Inhibiting oleic acid signaling or synthesis rescues NSC defects in 3xTg-AD mice

    Highlights •Early neural stem cell NSC impairment in 3xTg-AD mice correlates with SVZ subventricular zone niche lipid accumulations •Similar lipid accumulations are found in the SVZ in postmortem human AD brains •Accumulating SVZ lipids are locally generated, oleic acid-enriched triglycerides •Inhibiting oleic acid signaling or synthesis rescues NSC defects in 3xTg-AD mice Credit: Fernandes et al. Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease. Cell Stem Cell, 27 August 2015 DOI: 10.1016/j.stem.2015.08.001

    For the 1st time since the disease was described 109 years ago, researchers have discovered accumulations of fat droplets/ lipids in the brain of patients who died from the disease and h...

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