ACC tagged posts

Cognitive deficits accompany mood disorders and other psychiatric conditions, often with debilitating effects. Limited treatments currently exist, but studies in animals and humans have pointed to drugs such as the laxative prucalopride that activate serotonin receptors as a potential therapeutic for the symptoms...

Highlights •Prolyl hydroxylase 3 (PHD3) hydroxylates and activates the metabolic enzyme ACC2 •During nutrient abundance, the PHD3/ACC2 axis represses fatty acid oxidation (FAO) •PHD3 is low in AML, fueling a reliance on fats that can be targeted with FAO inhibitors •Re-expressing PHD3 limits FAO via ACC2 and suppresses AML in culture and in vivo

A handful of cancers favor fat over sugar, a propensity that has long mystified scientists. Now, a study from Harvard Medical School reveals how certain tumors develop a taste for fat as their life-sustaining fuel. The findings show how a signaling pathway that normally keeps fat-burning in check goes awry in some cancers, revving up fat consumption and fueling tumor growth.

Specifically, the study found a protein called prolyl hydroxylase ...

Brain function associated with higher cardiorespiratory fitness plays a role in increased cognitive performance in older adults, according to a new study. Specifically, the scientists found that dual-task processing in a core executive function brain region is associated with higher cardiorespiratory fitness and dual-task performance.

With fMRI scans in the Beckman Institute’s Biomedical Imaging Center, the researchers found that certain regions of the brain were activated more when performing two simultaneous tasks compared to a single task.

“The reason we looked at dual-task specifically is because it’s a measure of executive function, which is required for multiple cognitive processes, such as working memory, task management, coordination, and 3inhibition,” said Wong...