IMAGE: SONG TAN, PENN STATE
New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells—including cancer cells—regulate their genes.
The enzyme, LSD1, can “turn off gene expression by removing chemical flags (methyl groups) from the nucleosome—tightly packed units of DNA and protein in chromosomes. This LSD1 histone demethylase is over-expressed in multiple cancer types, resulting in disruption to normal cell development, and the new structure could inform therapeutic interventions that target the enzyme.
A paper by Penn State researchers describing the ...
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