ACE2 receptor tagged posts

Unique experiments involved ‘mini-organs’, animal research, donated human organs, volunteers and patients. Cambridge scientists have identified an off-patent drug that can be repurposed to prevent COVID-19 — and may be capable of protecting against future variants of the virus — in research involving a unique mix of ‘mini-organs’, donor organs, animal studies and patients.

The research, published today in Nature, showed that an existing drug used to treat a type of liver disease is able to ‘lock’ the doorway by which SARS-CoV-2 enters our cells, a receptor on the cell surface known as ACE2...

A team co-led by scientists at Scripps Research has found evidence that a compound contained in the medicinal and culinary herb rosemary could be a two-pronged weapon against the SARS-CoV-2 coronavirus that causes COVID-19.

The scientists, in experiments described in a paper published January 6, 2022 in the journal Antioxidants, found that the compound, carnosic acid, can block the interaction between the SARS-CoV-2 outer “spike” protein and the receptor protein, ACE2, which the virus uses to gain entry to cells.

The team also presented evidence, and reviewed evidence from prior studies, that carnosic acid has a separate effect in inhibiting a powerful inflammatory pathway—a pathway that is active in severe COVID-19 ...

The prevalence of auditory symptoms in COVID-19 patients is unknown, but infection of the inner ears may be responsible for hearing and balance problems.

Many Covid-19 patients have reported symptoms affecting the ears, including hearing loss and tinnitus. Dizziness and balance problems can also occur, suggesting that the SARS-CoV-2 virus may be able to infect the inner ear.

A new study from MIT and Massachusetts Eye and Ear provides evidence that the virus can indeed infect cells of the inner ear, including hair cells, which are critical for both hearing and balance...

Discovery opens new possibilities for treating COVID-19 by disrupting virus’ ability to bind the carbohydrate, potentially by using a repurposed drug. Researchers discovered that the SARS-CoV-2 virus can’t grab hold of cell receptor ACE2 without a carbohydrate called heparan sulfate, which is also found on lung cell surfaces – disrupting that interaction with a repurposed drug may help treat COVID-19.

A molecule known as ACE2 sits like a doorknob on the outer surfaces of the cells that line the lungs...